Results 41 to 50 of about 6,314,216 (264)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source

Spinal anesthesia; the Holy Grail? [PDF]

, 2017
Marieke Voet, Cornelis SlagtDepartment of Anesthesiology, Pain and Palliative Care, Radboud University Medical Center, Nijmegen, The NetherlandsAfter reading the paper recently published in Local and Regional Anesthesia by Whitaker et al:1 “Spinal ...
Slagt C, Slagt, C., Voet, M, Voet M, Cornelis Slagt, Marieke Voet   +5 more
core   +1 more source

Rapid quantification and PK-PD modeling of rocuronium bromide in beagles using portable mass spectrometer

Frontiers in Veterinary Science
Monitoring rocuronium bromide (Rocur) concentrations is crucial for assessing muscle relaxation in clinical anesthesia. However, no suitable instruments are currently available. This study explores the application of a portable mass spectrometer (MS) for
Xiaoxiao Li, Xiaoxiao Li, Pan Chang, Pan Chang, Xing Liu, Xing Liu, Deying Gong, Deying Gong, Wensheng Zhang, Wensheng Zhang   +9 more
doaj   +1 more source

Development of NMDA receptors contributes to the enhancement of electroencephalogram oscillations under volatile anesthetics in rats

Frontiers in Neural Circuits, 2022
BackgroundVolatile anesthetics including sevoflurane and isoflurane enhance oscillations of cortical electroencephalogram (EEG), partly by their modulations on glutamate-mediated excitatory synaptic transmission. Expression of NMDA receptors is increased
Mingyue Zhang, Mingyue Zhang, Yali Chen, Yali Chen, Jin Liu, Jin Liu, Yaoxin Yang, Yaoxin Yang, Rurong Wang, Donghang Zhang, Donghang Zhang, Tao Zhu   +11 more
doaj   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Department of Anesthesia. University of Iowa. Fall 2010. [PDF]

, 2010
University of Iowa Department of Anesthesia ...

core  

Dexmedetomidine with different concentrations added to local anesthetics in erector spinae plane block: a meta-analysis of randomized controlled trials

Frontiers in Medicine
BackgroundDexmedetomidine has been used as a perineural local anesthetic (LA) adjuvant to facilitate the potency of erector spinal plane block (ESPB). This quantitative review aimed to evaluate whether perineural dexmedetomidine for ESPB can improve the ...
Qian Li, Qian Li, Yaoxin Yang, Yaoxin Yang, Yu Leng, Yu Leng, Xiaowei Yin, Jin Liu, Cheng Zhou   +8 more
doaj   +1 more source

INTRAVENOUS LOCAL ANESTHESIA [PDF]

Journal of the American Medical Association, 1912
In searching for a method to avoid the difficulties of nerve-blocking anesthesia, Bier 1 developed the idea of Venenanasthesie which he reported at the thirty-seventh German Surgical Congress, in 1908. In 1909, he reported a series of 134 cases and gave in detail the technic of the method. 2 The anesthetizing solution is injected into the veins, in a
openaire   +2 more sources

Acute Kidney Injury After Mechanical Thrombectomy for Stroke in Patients With Pre‐Existing Renal Impairment

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives Acute kidney injury (AKI) is a common but often underrecognized complication in ischemic stroke patients undergoing mechanical thrombectomy, particularly among those with pre‐existing renal impairment. This study evaluated the incidence, risk factors, and clinical impact of AKI in this high‐risk population.
Michał Borończyk, Marcel Pilarek, Emilia Jaworska, Natalia Kardas, Oliwia Barnaś, Julia Woźniak, Iga Machała, Julia Węgrzynek‐Gallina, Joanna Siuda, Anna Hawrot‐Kawecka, Anetta Lasek‐Bal   +10 more
wiley   +1 more source

Ulnar nerve transposition at the elbow under local anesthesia: a patient satisfaction study [PDF]

, 2015
BACKGROUND Ulnar nerve decompression at the elbow traditionally requires regional or general anesthesia. We wished to assess the feasibility of performing ulnar nerve decompression and transposition at the elbow under local anesthesia.
Thierry Christen, Md Paolo Erba, Erba, P., Christen, Thierry, Wassim Raffoul, Raffoul, W., Roberti del Vecchio, Pietro M, J Reconstr Microsurg, Christen, T., Pietro M. Roberti Del Vecchio, Del Vecchio, P.M., Raffoul, Wassim, Erba, Paolo, Erba P, Roberti del Vecchio PM, Christen T, Raffoul W   +16 more
core   +1 more source