Results 141 to 150 of about 164,126 (358)

Silencing Myostatin Using In Vivo Self‐Assembled siRNA Protects Against Cancer‐ and Dexamethasone‐Induced Muscle Atrophy

Advanced Healthcare Materials, EarlyView.
This study reports an in vivo self‐assembled siRNA strategy that enables the liver to generate small extracellular vesicles (sEVs) tagged with a muscle‐targeting peptide (MSP) and naturally loaded with myostatin (MSTN)‐siRNA. These MSP‐tagged sEVs are systemically delivered to skeletal muscle, efficiently silence MSTN, promote muscle hypertrophy, and ...
Xin Yin, Azhar Anwar, Jiehao Chen, Qinghao Sun, Likun Zhou, Jie Tang, Jingwei Guo, Linbo Yan, Yongci Chen, Feng Yin, Chen‐Yu Zhang, Zigang Li, Jizheng Ma, Liyuan Sheng, Xi Chen   +14 more
wiley   +1 more source

Two restraining devices in connection to surgical castration with or without local anesthesia: effects on piglet stress

Porcine Health Management
Background Surgical castration causes severe pain to young piglets. In addition, piglets experience intense stress from handling and restraining during the procedure.
Ann-Helena Hokkanen, Mathilde Coutant, Mari Heinonen, Marianna Norring, Magdy Adam, Claudio Oliviero, Tiina Bergqvist, Anna Valros   +7 more
doaj   +1 more source

ROS‐Triggered Microgels for Programmable Drug Release in Volumetric Muscle Loss Repair

Advanced Healthcare Materials, EarlyView.
Reduced graphene oxide‐incorporated hyaluronic acid microgels are developed as ROS‐responsive, injectable platforms for curcumin delivery in volumetric muscle loss. The microgels exhibit strong antioxidative activity, high drug‐loading capacity, and ROS‐triggered release.
Seungjun Lee, Goeun Choe, Junghyun Kim, Junggeon Park, Jia Yi Erica Kok, Jae Young Lee   +5 more
wiley   +1 more source

Selection of the safest local anesthetic for dental treatment in medically compromised patients: A comprehensive review

Saudi Journal of Anaesthesia
Local anesthetics are essential in dental practice, but their systemic effects can pose significant risks for medically compromised patients. This review aims to identify and evaluate the safest local anesthetic agents for use in dental procedures in ...
Giath Gazal, Esam Omar, Husam Abdullah Alofi, Mohammad Zakaria Nassani   +3 more
doaj   +1 more source

Local anesthetics induce fast Ca2+ efflux through a nonenergized state of the sarcoplasmic reticulum Ca(2+)-ATPase.

, 1992
Herman Wolosker, Antônio Guilherme Pacheco, Leopoldo de Meis   +2 more
openalex   +1 more source

Synthetic Hydrogels Incorporating Hydrolytic/Nonhydrolytic Macromer Ratios Exhibit Improved Tunability of In Vivo Degradation and Immune Responses

Advanced Healthcare Materials, EarlyView.
A synthetic 4‐arm maleimide‐terminated poly(ethylene glycol) (PEG‐4MAL) hydrogel system that combines hydrolytic ester‐linked macromer (PEG‐4eMAL) with nondegradable amide‐linked macromer (PEG‐4aMAL) in various stoichiometric ratios to tune the degradability rate. The macromers are crosslinked with dithiothreitol via thiol‐maleimide click reaction. The
Michael D. Hunckler, Sophia Kioulaphides, Karen E. Martin, Angelica L. Torres, Graham F. Barber, Stephen W. Linderman, Rebecca S. Schneider, Andrés J. García   +7 more
wiley   +1 more source

Tunicate‐Inspired Carboxymethyl Cellulose Hydrogel Filler for Treating Age‐Associated Vocal Fold Atrophy

Advanced Healthcare Materials, EarlyView.
The pyrogallol‐conjugated carboxymethylcellulose (CMC‐PG) hydrogel is applicated as a filler for the treatment of presbylaryngis, a vocal fold atrophy. CMC‐PG provides a bulking effect to the vocal folds. CMC‐PG is readily injectable and tissue adhesive, enabling sustained release of growth factor over long period.
Jihoon Jeon, Sang‐Yoon Han, Ji Suk Choi, Soojeong Choi, Dongkyun Shin, Mikyung Shin, Seong Keun Kwon, Seung‐Woo Cho   +7 more
wiley   +1 more source

REPORTS ON LOCAL ANESTHETICS IN LARYNGOLOGY [PDF]

, 1919
Ross Hall Skillern
openalex   +1 more source

Injectable Dual‐Crosslinked Poly(oligo(Ethylene Glycol) Methacrylate) Hydrogels Inspired by Mussel Adhesion for Cutaneous Wound Healing and Functional Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Injectable POEGMA‐DA hydrogels, dual‐crosslinked via dopamine self‐polymerization and dynamic hydrazone bonds, provide a safer alternative to invasive wound closure methods and toxic bioadhesives. Mimicking skin‐like mechanics, they achieve effective tissue adhesion for acute dermal wounds, supporting improved healing outcomes, including reducing ...
Gurpreet Kaur Randhawa, Meghan Kostashuk, Zhicheng Pan, Nils Nordstrom, Thomas Kalab, Erica Winterhelt, Todd Hoare   +6 more
wiley   +1 more source

Network efficiency and posterior alpha patterns are markers of recovery from general anesthesia: A high-density electroencephalography study in healthy volunteers [PDF]

, 2017
Avidan, Michael S, Bel-Behar, Tarik, Blain-Moraes, Stefanie, Golmirzaie, Goodarz, Janke, Ellen, Kelz, Max B, Mashour, George A, Palanca, Ben J.A., Picton, Paul, Tarnal, Vijay, Vanini, Giancarlo   +10 more
core   +2 more sources