Results 271 to 280 of about 164,881 (359)

Taurocholic Acid Is Associated With Disturbed Functional Connectivity in the Hippocampus of Patients With Depression

Advanced Science, EarlyView.
This study identifies elevated taurocholic acid (TCA) in Major Depressive Disorder patients. Gut microbiome‐associated TCA impairs hippocampal neurogenesis, triggers microglia activation, and elicits depression‐like behavior in mice via the S1PR2. In patients, functional neuroimaging reveals that serum TCA levels correlate with altered functional ...
Xiaoying Cai, Taipeng Sun, Mengzhen Feng, Gang Chen, Junchi Zhou, Hong Zhuang, Dan Wang, Ying Chen, Zhen Cheng, Zhi Xu, Xiao Zheng, Xueli Zhang, Yonggui Yuan   +12 more
wiley   +1 more source

Structure-Property Relationships in Novel Series of Photoswitchable Local Anesthetic Ethercaine Derivatives: Emphasis on Biological and Photophysical Properties. [PDF]

Int J Mol Sci
Noev A, Likhobabina D, Sutemieva J, Plyutinskaya A, Cheshkov D, Morozova N, Vinokurova A, Vasil'ev Y, Suvorov N, Nemtzova E, Pankratov A, Filonenko E, Shegay P, Kaprin A, Grin M.   +14 more
europepmc   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source

Transient Unilateral Blepharoptosis Following Upper Blepharoplasty: A Case Report and Considerations for Local Anesthetic Use. [PDF]

Cureus
Papanikolaou GE, Bouranta K, Smiris TI, Varvarousis DN.   +3 more
europepmc   +1 more source

Inactivation of AXL in Cardiac Fibroblasts Alleviates Right Ventricular Remodeling in Pulmonary Hypertension

Advanced Science, EarlyView.
Pulmonary hypertension (PH) is a progressive condition with high morbidity and mortality, largely owing to right ventricular (RV) failure resulting from maladaptive remodeling. Our study provides strong evidence in support of a critical, detrimental role for AXL as a previously unrecognized determinant driving RV fibrotic pathology in PH.
Li‐Wei Wu, Min Chen, Chen‐Yu Jiang, Dai‐Ji Jiang, Xu Zhang, Xiao‐He Xu, Yi‐Wei Liu, Bei Feng, Lin‐Cai Ye, Yang‐Yang He, Xu Huang, Yi‐Chi Zhang, Xing‐Liang Zhou, Yi Shen, Tian‐Yu Liu, Li‐Jun Fu, Yi Yan, Hao Zhang   +17 more
wiley   +1 more source

Advanced Hydrogel Systems for Local Anesthetic Delivery: Toward Prolonged and Targeted Pain Relief. [PDF]

Gels
Jeong JO, Kim M, Kim S, Lee KK, Choi H.
europepmc   +1 more source

Nurr1 Orchestrates Claustrum Development and Functionality

Advanced Science, EarlyView.
Nurr1 (Nr4a2) is the master transcription factor to control claustrum morphogenesis and cell fate decision postmitotically by inhibiting intracellular G‐protein signaling. Nurr1 deficiency alters the transcriptomic profiles of subcortical claustral neurons into neocortical insular neurons, resulting in defected claustrum development, impaired axonal ...
Kuo Yan, Andrew G. Newman, Pauline Lange, Susanne Müller, Marco Foddis, Stefan Paul Koch, Philipp Böhm‐Sturm, Maron Mantwill, Carsten Finke, Penghui Deng, Melissa Long, Dietmar Schmitz, Victor Tarabykin   +12 more
wiley   +1 more source

The Problem to a Solution: A Case of Local Anesthetic-Related Acute Pancreatitis. [PDF]

Cureus
Robles J, Rogando D, Ranjbar T, Mukherjee I, Clarke E, Mukharjee S.   +5 more
europepmc   +1 more source

Role of the lipid matrix in the action of local anesthetics

Anke Mautner-Culetto, Marcel Huhn, Simon Schwarz, Li Tian, Mert Hamballer, Sergii Afonin, Boris Martinac, Gernot Buth, Anthony Watts, Justus Benrath, Anne S. Ulrich, Stephan L. Grage   +11 more
openalex   +1 more source

Peripheral Neuropathic Pain and Pain Related to Complex Regional Pain Syndrome with and without Fixed Dystonia – Efficient Therapeutic Approach with Local Anesthetics

, 2020
T Michels
openalex   +1 more source