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Safety of local anesthetics, [PDF]
Anais Brasileiros de Dermatologia, 2020 Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types.
Ana Carolina Figueiredo Pereira Cherobin +1 more
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Mechanisms of Cancer Inhibition by Local Anesthetics
Frontiers in Pharmacology, 2021 The use of local anesthetics during surgical treatment of cancer patients is an important part of perioperative analgesia. In recent years, it has been showed that local anesthetics can directly or indirectly affect the progression of tumors.
Malay Kishore Dutta +2 more
exaly +4 more sources
BMC Anesthesiology, 2020 Background Retrospective analysis and pre-clinical studies suggest that local anesthetics have anti-tumoral effects. However, the association between cancer recurrence and the use of local anesthesia is inconclusive and most reports are based on single ...
Guanhua Zhu +3 more
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Local anesthetics elicit immune-dependent anticancer effects
Journal for ImmunoTherapy of Cancer, 2022 Background Retrospective clinical trials reported a reduced local relapse rate, as well as improved overall survival after injection of local anesthetics during cancer surgery. Here, we investigated the anticancer effects of six local anesthetics used in
Shuai Zhang +14 more
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Effects of local anesthetics on breast cancer cell viability and migration
BMC Cancer, 2018 Background Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery.
Ru Li +5 more
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Paresthesia in dentistry: The ignored neurotoxicity of local anesthetics [PDF]
Heliyon, 2023 Local anesthetics are frequently used by dentists to relieve localized discomfort of the patient and improve treatment conditions. The risk of paresthesia after local anesthesia is frequently encountered in dental clinics.
Yong-zhen Tan +4 more
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Mydriasis mediated by local anesthetics: an unexpected adverse event or new therapeutic indication? [PDF]
Therapeutic Advances in Drug SafetyThe increasing off-label use of medications needs a robust pharmacovigilance system. This is particularly crucial given the abundance of scientific data that can be harnessed to ensure a product’s safety.
Homero Contreras-Salinas +4 more
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Trial watch: local anesthetics in cancer therapy [PDF]
OncoImmunologyPreclinical evidence indicates potent antitumor properties of local anesthetics. Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic as well as indirect immunemediated effects that together ...
Killian Carnet Le Provost +3 more
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Solvent-Driven Enrichment and Multiplex Analysis of Local Anesthetics by Thin-Layer Chromatography Coupled with Surface-Enhanced Raman Spectroscopy [PDF]
MoleculesLocal anesthetics have been widely used in clinical analgesia due to their ability to provide effective regional pain management. Accurate measurement of local anesthetics in body fluids is crucial for ensuring patient medication safety and optimizing ...
Huimin Sui +9 more
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Research advances in the roles of local anesthetics in tumor metastasis and recurrence [PDF]
Jichu yixue yu linchuang, 2022 Anesthetics are commonly used in the perioperative treatment of tumor. The choice of different anesthetics and anesthesia techniques will affect the proliferation, metastasis, recurrence and prognosis of cancer.
LIU Chang, GUO Xiang-yang
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