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Safety of local anesthetics, [PDF]

Anais Brasileiros de Dermatologia, 2020
Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types.
Ana Carolina Figueiredo Pereira Cherobin, Glaysson Tassara Tavares   +1 more
doaj   +3 more sources

Mechanisms of Cancer Inhibition by Local Anesthetics

Frontiers in Pharmacology, 2021
The use of local anesthetics during surgical treatment of cancer patients is an important part of perioperative analgesia. In recent years, it has been showed that local anesthetics can directly or indirectly affect the progression of tumors.
Yiguo Zhang, Yixin Jing, Rui Pan, Ke Ding, Rong Chen, Rong Chen, Qingtao Meng, Qingtao Meng   +7 more
doaj   +2 more sources

Differential effects and mechanisms of local anesthetics on esophageal carcinoma cell migration, growth, survival and chemosensitivity

BMC Anesthesiology, 2020
Background Retrospective analysis and pre-clinical studies suggest that local anesthetics have anti-tumoral effects. However, the association between cancer recurrence and the use of local anesthesia is inconclusive and most reports are based on single ...
Guanhua Zhu, Ling Zhang, Jiapeng Dan, Qiong Zhu   +3 more
doaj   +2 more sources

Local anesthetics elicit immune-dependent anticancer effects

Journal for ImmunoTherapy of Cancer, 2022
Background Retrospective clinical trials reported a reduced local relapse rate, as well as improved overall survival after injection of local anesthetics during cancer surgery. Here, we investigated the anticancer effects of six local anesthetics used in
Shuai Zhang, Peng Liu, Wei Xie, Fabrice Barlesi, Guido Kroemer, Oliver Kepp, Juliette Humeau, Jonathan Pol, Liwei Zhao, Lucillia Bezu, Alejandra Wu Chuang, Allan Sauvat, Giulia Cerrato, Julie Le Naour, Peter van Endert   +14 more
doaj   +2 more sources

Effects of local anesthetics on breast cancer cell viability and migration

BMC Cancer, 2018
Background Breast cancer accounts for nearly a quarter of all cancers in women worldwide, and more than 90% of women diagnosed with breast cancer undergo mastectomy or breast-conserving surgery.
Ru Li, Chunyun Xiao, Hengrui Liu, Yujie Huang, James P. Dilger, Jun Lin   +5 more
doaj   +2 more sources

Effects of simultaneous administration of local anesthetics on seizure induced threshold: an experimental study in rats [PDF]

BMC Anesthesiology
Background The effect of the simultaneous administration of local anesthetics, whether synergistic, additive, or antagonistic, has not yet been established.
Yoshie Noji, Masahiro Murakawa, Shinju Obara, Keisuke Yoshida, Atsuyuki Hosono, Satoki Inoue   +5 more
doaj   +2 more sources

Paresthesia in dentistry: The ignored neurotoxicity of local anesthetics [PDF]

Heliyon, 2023
Local anesthetics are frequently used by dentists to relieve localized discomfort of the patient and improve treatment conditions. The risk of paresthesia after local anesthesia is frequently encountered in dental clinics.
Yong-zhen Tan, Rong-jia Shi, Bo-wen Ke, Ya-ling Tang, Xin-hua Liang   +4 more
doaj   +2 more sources

Advances of Nano-Structured Extended-Release Local Anesthetics

Nanoscale Research Letters, 2020
Extended-release local anesthetics (LAs) have drawn increasing attention with their promising role in improving analgesia and reducing adverse events of LAs.
Yumiao He, Linan Qin, Yuguang Huang, Chao Ma   +3 more
doaj   +2 more sources

Mydriasis mediated by local anesthetics: an unexpected adverse event or new therapeutic indication? [PDF]

Therapeutic Advances in Drug Safety
The increasing off-label use of medications needs a robust pharmacovigilance system. This is particularly crucial given the abundance of scientific data that can be harnessed to ensure a product’s safety.
Homero Contreras-Salinas, Janet Cristina Vázquez-Beltrán, María Soledad Romero-López, Oscar Olvera-Montaño, Lourdes Yolotzin Rodríguez-Herrera   +4 more
doaj   +2 more sources

On controversial issues of systemic toxicity of local anesthetics

Вестник анестезиологии и реаниматологии, 2020
The letter draws attention to the provisions on the use of fat emulsion when systemic toxicity of local anesthetics develops that was published in the article titled Disputed Issues of Systemic Toxicity of Local Anesthetics.
R. E. Lakhin
doaj   +3 more sources