Electrostatic Contributions of Aromatic Residues in the Local Anesthetic Receptor of Voltage-Gated Sodium Channels [PDF]
, 2008 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels, decreasing excitability of nerve and muscle cells. Channel inhibition by members of this family of cationic, hydrophobic drugs relies on the presence of highly ...
Ahern, Christopher A. +3 more
core +2 more sources
Efficacy of dental local anesthetics: A review
Journal of dental anesthesia and pain medicine, 2018 The objective of this review was to investigate the efficacy of dental local anesthetics, as it is well known among clinicians that local anesthesia may be challenging in some circumstances.
N. Badr, J. Aps
semanticscholar +1 more source
Advances in the use of local anesthetic extended-release systems in pain management
Drug DeliveryPain management remains among the most common and largely unmet clinical problems today. Local anesthetics play an indispensable role in pain management.
Yulu Chen +6 more
doaj +1 more source
Sweet-Tasting Ionic Conjugates of Local Anesthetics and Vasoconstrictors
Molecules, 2021 Local anesthetics are widely utilized in dentistry, cosmetology, and medicine. Local anesthesia is essential to providing a pain-free experience during dental and local surgeries as well as cosmetic procedures.
John K. Neubert +9 more
doaj +1 more source
Liquid general anesthetics lower critical temperatures in plasma membrane vesicles [PDF]
, 2013 A large and diverse array of small hydrophobic molecules induce general anesthesia. Their efficacy as anesthetics has been shown to correlate both with their affinity for a hydrophobic environment and with their potency in inhibiting certain ligand gated ion channels.
arxiv +1 more source
Membrane Nanodomains Homeostasis During Propofol Anesthesia as Function of Dosage and Temperature [PDF]
, 2020 Some anesthetics bind and potentiate gamma-aminobutyric-acid-type receptors, but no universal mechanism for general anesthesia is known. Furthermore, often encountered complications such as anesthesia induced amnesia are not understood. General anesthetics are hydrophobic molecules easily dissolving into lipid bilayers.
arxiv +1 more source
Paresthesia in dentistry: The ignored neurotoxicity of local anesthetics
Heliyon, 2023 Local anesthetics are frequently used by dentists to relieve localized discomfort of the patient and improve treatment conditions. The risk of paresthesia after local anesthesia is frequently encountered in dental clinics.
Yong-zhen Tan +4 more
doaj
The Twice Extracting Method of the Local Anesthetics in Human Blood for the Gas Chromatographic Study [PDF]
, 1980 It has been thought important to study the concentration levels of the local anesthetics, because to which toxic symptoms induced by local anesthesia in the oral region is considered proportional.
山岡 稔 +4 more
core +1 more source
All local anesthetics bind to the biomembrane by its nitrogen atom in the molecule [PDF]
, 2004 The interaction between various local anesthetics and the phospholipid membrane was examined by ^1HNMR (Nuclear Magnetic Resonance) spectroscopy. In order to measure the extent of proximity of various local anesthetics to the membrane, We examinined the ...
Hanako OHKE +11 more
core +1 more source