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Safety of local anesthetics, [PDF]
Anais Brasileiros de Dermatologia, 2020 Local anesthetics are essential medications for the conduction of dermatological procedures. They stop the depolarization of nerve fibers and are divided into two main categories, the amide and ester types.
Ana Carolina Figueiredo Pereira Cherobin +1 more
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Effects of simultaneous administration of local anesthetics on seizure induced threshold: an experimental study in rats [PDF]
BMC AnesthesiologyBackground The effect of the simultaneous administration of local anesthetics, whether synergistic, additive, or antagonistic, has not yet been established.
Yoshie Noji +5 more
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Paresthesia in dentistry: The ignored neurotoxicity of local anesthetics [PDF]
Heliyon, 2023 Local anesthetics are frequently used by dentists to relieve localized discomfort of the patient and improve treatment conditions. The risk of paresthesia after local anesthesia is frequently encountered in dental clinics.
Yong-zhen Tan +4 more
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Mydriasis mediated by local anesthetics: an unexpected adverse event or new therapeutic indication? [PDF]
Therapeutic Advances in Drug SafetyThe increasing off-label use of medications needs a robust pharmacovigilance system. This is particularly crucial given the abundance of scientific data that can be harnessed to ensure a product’s safety.
Homero Contreras-Salinas +4 more
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Trial watch: local anesthetics in cancer therapy [PDF]
OncoImmunologyPreclinical evidence indicates potent antitumor properties of local anesthetics. Numerous underlying mechanisms explaining such anticancer effects have been identified, suggesting direct cytotoxic as well as indirect immunemediated effects that together ...
Killian Carnet Le Provost +3 more
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Research advances in the roles of local anesthetics in tumor metastasis and recurrence [PDF]
Jichu yixue yu linchuang, 2022 Anesthetics are commonly used in the perioperative treatment of tumor. The choice of different anesthetics and anesthesia techniques will affect the proliferation, metastasis, recurrence and prognosis of cancer.
LIU Chang, GUO Xiang-yang
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Direct Cytotoxic and Indirect, Immune-Mediated Effects of Local Anesthetics Against Cancer
Frontiers in Oncology, 2022 Local anesthetics are frequently employed during surgery in order to control peri- and postoperative pain. Retrospective studies have revealed an unexpected correlation between increased long-term survival and the use of local anesthetics during ...
Alejandra Wu Chuang +9 more
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Stem Cell Research & Therapy, 2021 Background A large number of preclinical studies have shown that local anesthetics have a direct inhibitory effect on tumor biological activities, including cell survival, proliferation, migration, and invasion. There are few studies on the role of local
Xiaoqing Fan +7 more
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