Results 11 to 20 of about 6,711,395 (246)

Evidence for Local Antibiotics in the Prevention of Infection in Orthopaedic Trauma. [PDF]

J Clin Med, 2022
Prevention of fracture-related infection (FRI) remains a substantial challenge in orthopaedic trauma care. There is evolving evidence to support the use of local antibiotics for both the prevention and treatment of musculoskeletal infection.
Flores MJ, Brown KE, Morshed S, Shearer DW.   +3 more
europepmc   +2 more sources

The use of Stimulan in bone and joint infections: a prospective multicentre study

Bone & Joint Open, 2023
Aims: Musculoskeletal infection is a devastating complication in both trauma and elective orthopaedic surgeries that can result in significant morbidity.
Praveen Mereddy, Somasekhar R. Nallamilli, Veda P. Gowda, Srinivas Kasha, Shashi K. Godey, Rajyalakshmi R. Nallamilli, Rohit GPRK, Venu G. R. Meda   +7 more
doaj   +1 more source

Acknowledgment to Reviewers of Antibiotics in 2020

, 2021
Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Antibiotics maintains its standards for the high quality of its published papers [...
Antibiotics Editorial Office Antibiotics Editorial Office, Antibiotics Editorial Office, null null   +2 more
core   +2 more sources

Toxic Effect of Vancomycin on Viability and Functionality of Different Cells Involved in Tissue Regeneration

Antibiotics, 2020
To prevent infections local delivery of antibiotics is a useful tool. Especially in bone fractures, vancomycin impregnated bone cements are often used allowing high concentrations of antibiotics at the infection side without high serum concentrations ...
Joy Braun, Stefanie Eckes, Pol Maria Rommens, Katja Schmitz, Daniela Nickel, Ulrike Ritz   +5 more
doaj   +1 more source

Local Fixation of Colistin With Fibrin Spray: An in vivo Animal Study for the Therapy of Skin and Soft Tissue Infections

Frontiers in Surgery, 2022
ObjectiveSkin and soft tissue infections (SSTI) are a commonly known entity of diseases associated with difficult treatment procedures. The current gold standard when there is a rapidly progressing infection of soft tissues with a risk of sepsis is ...
Maren Janko, Fabian Dust, Pia Viktoria Wagner, Robert Gurke, Robert Gurke, Johannes Frank, Dirk Henrich, Ingo Marzi, René Danilo Verboket   +8 more
doaj   +1 more source

Local Antibiotic Delivery Options in Prosthetic Joint Infection

Antibiotics, 2023
Prosthetic Joint Infection (PJI) causes significant morbidity and mortality for patients globally. Delivery of antibiotics to the site of infection has potential to improve the treatment outcomes and enhance biofilm eradication.
William Steadman, Paul R. Chapman, Michael Schuetz, Beat Schmutz, Andrej Trampuz, Kevin Tetsworth   +5 more
doaj   +1 more source

A Placebo-Controlled Trial to Evaluate Two Locally Delivered Antibiotic Gels (Piperacillin Plus Tazobactam vs. Doxycycline) in Stage III–IV Periodontitis Patients

Medicina, 2023
Background and objectives: this study aims to evaluate the clinical and microbiological effects of a single subgingival administration of a locally delivered antibiotic gel containing piperacillin plus tazobactam and compare it with a slow-release ...
Ioana Ilyes, Darian Rusu, Viorelia Rădulescu, Octavia Vela, Marius Ion Boariu, Alexandra Roman, Petra Surlin, Giorgios Kardaras, Simina Boia, Salvatore Chinnici, Holger Friedrich Rudolf Jentsch, Stefan-Ioan Stratul   +11 more
doaj   +1 more source

Antibiotic-Loaded Hydrogel Coating to Reduce Early Postsurgical Infections in Aseptic Hip Revision Surgery: A Retrospective, Matched Case-Control Study

Microorganisms, 2020
Periprosthetic joint infections (PJIs) are a cause of frequent implant failure in revision hip replacement surgery. The purpose of this study is to evaluate the onset of early postoperative infections in patients who underwent hip surgery with cementless
Daniele De Meo, Valeria Calogero, Lorenzo Are, Armando U. Cavallo, Pietro Persiani, Ciro Villani   +5 more
doaj   +1 more source

In Vitro Evaluation of Antimicrobial Activity of Minocycline Formulations for Topical Application in Periodontal Therapy

Pharmaceutics, 2020
Periodontal therapy using antimicrobials that are topically applied requires slow or controlled release devices. The in vitro antimicrobial activity of biodegradable polymer formulations that contain a new minocycline lipid complex (P-MLC) was evaluated.
Jan-Luca Schmid, Martin Kirchberg, Sandra Sarembe, Andreas Kiesow, Anton Sculean, Karsten Mäder, Mirko Buchholz, Sigrun Eick   +7 more
doaj   +1 more source

An Antibiotic-Loaded Hydrogel Demonstrates Efficacy as Prophylaxis and Treatment in a Large Animal Model of Orthopaedic Device-Related Infection

Frontiers in Cellular and Infection Microbiology, 2022
Local antibiotic therapy is increasingly being recognised for its role in preventing and treating orthopaedic device-related infection (ODRI). A bioresorbable, injectable gentamicin-loaded hydrogel has been developed to deliver local antibiotics at the ...
Willemijn Boot, Andrew Lewis Foster, Andrew Lewis Foster, Andrew Lewis Foster, Andrew Lewis Foster, Olivier Guillaume, David Eglin, Tanja Schmid, Matteo D’Este, Stephan Zeiter, Robert Geoff Richards, Thomas Fintan Moriarty   +11 more
doaj   +1 more source