Results 41 to 50 of about 6,749,458 (277)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

The environmental spending needs of Scotland’s local authorities [PDF]

, 2007
Scottish citizens benefit from 19% more public spending per head than English citizens. The ‘Barnett formula’ is slowly reducing the gap, but very little is known about the countries’ relative needs and hence about how far the present gap is defensible ...
King, David N, Ball, Robert, Pashley, Matthew   +2 more
core   +1 more source

Triangular negotiations of island sovereignty: Indigenous and customary authorities - metropolitan states - local metropolitan authorities

Island Studies Journal, 2020
The benefits of subnational island jurisdiction (SNIJ) status are well detailed, but less attention has been given to the diffusion of economic, social and political benefits associated with these islands’ Islandian sovereignty among diverse island ...
Cadey Korson, Sybille Poaouteta, Gerard Prinsen   +2 more
doaj   +2 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Timely response and containment of 2022 Cholera outbreak along lake Tanganyika in Kigoma region, Tanzania

Bulletin of the National Research Centre
Background Cholera outbreaks have been reported worldwide, causing excessive health and economic burdens. From January 2023 to March 2024, about 824,479 cholera cases and 5,900 cholera deaths were reported by 31 countries, Tanzania being among them.
Mololo Noah Mwanjala, Jesca Lebba, Grace Mosi, Nesphory Sungu, Frank Sudai, George Mrema, Annamary Batoleki, Maria E. Kelly, Nyanda C. Justine, Agricola Joachim, Mtebe Majigo   +10 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

Extracting homogenous data from heterogenous diseases: RaraSwed, the Swedish national rare disease quality registry

BMC Global and Public Health
In the Swedish universal healthcare system, persons living with rare diseases (PLWRD) face major challenges in receiving diagnosis and accessing care,stemming in part from heterogeneity of disease and systemic barriers to care. This contributes to health
Sanna Mansoob, Dan Hellström, Magnus Burstedt, Malin Grände, Cecilia Gunnarsson, Stephanie Juran, Lovisa Lovmar, Katarina Sandgren, Maria Johansson Soller, Anna Wedell, Cecilia Soussi Zander, Alexandra Wennberg, Marie Stenmark Askmalm   +12 more
doaj   +1 more source

Normative powers of Serbian local authorities [PDF]

Pravni Zapisi, 2019
Authors analyse Serbian legislation in respect of regulatory autonomy of local governments, i.e. the authorisation of different local government bodies to pass ordinance and bylaws in realisation of local competences.
Jerinić Jelena, Milosavljević Bogoljub
doaj