Results 41 to 50 of about 334,763 (303)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Bulletin of the National Research CentreBackground Cholera outbreaks have been reported worldwide, causing excessive health and economic burdens. From January 2023 to March 2024, about 824,479 cholera cases and 5,900 cholera deaths were reported by 31 countries, Tanzania being among them.
Mololo Noah Mwanjala +10 more
doaj +1 more source
Normative powers of Serbian local authorities [PDF]
Pravni Zapisi, 2019 Authors analyse Serbian legislation in respect of regulatory autonomy of local governments, i.e. the authorisation of different local government bodies to pass ordinance and bylaws in realisation of local competences.
Jerinić Jelena, Milosavljević Bogoljub
doaj
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Local government and leisure:: A study of two local authorities and their responses to the growth of leisure [PDF]
, 1992 Local authorities have a long history of providing recreation and leisure services, but since the 1970s leisure departments have expanded with a corresponding growth in the number and importance of professional officers to run them.
Liddle, Joyce
core
Scandinavian Journal of Primary Health CareObjective Quality measures in healthcare are crucial for improving outcomes and ensuring patient safety. This study investigated the evolution, implementation, and impact of Primary Care Quality (PCQ).
Jörgen Månsson +7 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Effectiveness of strategy implementation using the balanced scorecard in local government authorities [PDF]
, 2013 This study focuses on two issues; first is to examine how Local Government Authorities (LGAs) implement their strategies and secondly how the Balanced Scorecard is adopted as a tool for measuring effectiveness of strategy implementation in public ...
Akerele, Emmanuel Kayode +4 more
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source