Results 61 to 70 of about 443,473 (282)

Longitudinal study of local authority child and family social workers (wave 1) Findings from a 5 year study of local authority child and family social workers in England. [PDF]

, 2019
The longitudinal study investigates recruitment, retention and career progression in local authority child and family social work over 5 years. This is the first of 5 reports.
Coburn, S, DfE, Felton, J, IFF, Johnson, C, McCaughan, S, McLaughlin, H, Pollock, S, Sanders-Earley, A, Scholar, HF, Winterbotham, M   +10 more
core   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Need for Revised Resolution Regimes and Supervisory Arrangements [PDF]

, 2011
In October 2010, having drawn crucial lessons fom the Financial Crisis which was triggered in 2007, and whose impact was still evident at the time, the Financial Stability Board Recommendations on systemically important financial institutions „called ...
Ojo, Mariane.B.
core   +2 more sources

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Evolutionary game analysis and regulatory countermeasure research on ship emission supervision

Frontiers in Marine Science
Ship emission supervision is an important component of the development of green shipping. During the implementation of policies in the pollutant emission control areas of ships, in response to the bottlenecks in regulatory manpower, technology, and cost,
Lin Xue, Wei He
doaj   +1 more source

Régularité morphologique et volontarisme social

Mélanges de la Casa de Velázquez, 2009
Very little is known of the morphogenesis of mediaeval villages in southern Portugal; on the basis of a number of cases that have been better elucidated by field studies and written sources (other than old plans), the article proposes some means of ...
Stéphane Boissellier
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

THE MEANING OF AUTHORITY RELATION OF CENTRAL GOVERNMENT AND LOCAL GOVERNMENT IN THE LAND SECTOR ACCORDING TO THE 1945 CONSTITUTION OF THE REPUBLIC OF INDONESIA

Yustisia, 2017
In this study, there are two (2) issues that were examined. First, how the Central Government and Local Government gained authority in the land sector.
Nurus Zaman
doaj   +1 more source

Legal Analysis of Local Government Authority in Doctor Supervision Post Law No. 17/2023: Between Autonomy and Regulatory Vacuum

Formosa Journal of Multidisciplinary Research
This study provides a juridical analysis of the authority of local governments in supervising the medical profession following the enactment of Law Number 17 of 2023 concerning Health. Its main focus lies in the tension between the principle of regional autonomy and the regulatory vacuum, which creates ambiguity in local-level implementation.
Ivan Kurniawan Bassar, Aneta Budi Putra, R Deden Sucahyana, Nizar Nizar, Reny Pordaningsih   +4 more
openaire   +1 more source