Results 41 to 50 of about 13,821 (251)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Investigation of the solution of a boundary value problem with variable coefficients whose principal part is the Cauchy–Riemann equation

Қарағанды университетінің хабаршысы. Математика сериясы
This study is devoted to obtaining an analytical expression for the solution of a non-local boundary value problem for a linear inhomogeneous differential equation with variable coefficients, which principle part is the Cauchy–Riemann equation.
M. Rasulov, N. Aliyev, B. Sinsoysal
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Computational Solution of an Inverse Boundary-Value Problem for Heat Transfer in a Composite Material

Applied Sciences
In the numerical simulation of composite material models, it is often necessary to recover boundary values of the solution to parabolic problems from integral constraints.
Miglena N. Koleva, Lubin G. Vulkov
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Fredholm integral equations neural operator (FIE-NO) for data-driven boundary value problems

Machine Learning. Engineering
In this paper, we present a novel neural operator method, termed FIE-NO, inspired by Fredholm integral equations (FIE) and random Fourier features (RFF), tailored for solving data-driven boundary value problems (BVPs) with irregular boundaries.
Haoyang Jiang, Yongzhi Qu
doaj   +1 more source

A combined problem with local and nonlocal conditions for a class of mixed-type equations

Қарағанды университетінің хабаршысы. Математика сериясы
This paper investigates the issues of existence and uniqueness of a solution to a combined boundary value problem with local and nonlocal conditions for a specific class of mixed elliptic-hyperbolic-type equations with singular coefficients.
M. Mirsaburov, A.B. Makulbay, G.M. Mirsaburova   +2 more
doaj   +1 more source

On the action of a semi-Markov process on a system of differential equations

Mathematical Modelling and Analysis, 2012
We deal with a model equation for stochastic processes that results from the action of a semi-Markov process on a system of ordinary differential equations. The resulting stochastic process is deterministic in pieces, with random changes of the motion at
Mario Annunziato
doaj   +1 more source

Effects of Volume Changes on the Thermal Performance of PCM Layers Subjected to Oscillations of the Ambient Temperature: Transient and Steady Periodic Regimes

Molecules, 2022
The Stefan problem regarding the formation of several liquid–solid interfaces produced by the oscillations of the ambient temperature around the melting point of a phase change material has been addressed by several authors. Numerical and semi-analytical
Rubén D. Santiago-Acosta, Ernesto M. Hernández-Cooper, Rolando Pérez-Álvarez, José A. Otero   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source