Results 61 to 70 of about 12,629 (265)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A Pure Contour Formulation for the Meshless Local Boundary Integral Equation Method in Thermoelasticity

Computer Modeling in Engineering & Sciences, 2001
A new meshless method for solving stationary thermoelastic boundary value problems is proposed in the present paper. The moving least square (MLS) method is used for the approximation of physical quantities in the local boundary integral equations (LBIE). In stationary thermoelasticity, the temperature and displacement fields are uncoupled.
Sladek, J., Sladek, V., Atluri, S. N.
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

About a Problem for Loaded Parabolic-Hyperbolic Type Equation with Fractional Derivatives

International Journal of Differential Equations, 2016
An existence and uniqueness of solution of local boundary value problem with discontinuous matching condition for the loaded parabolic-hyperbolic equation involving the Caputo fractional derivative and Riemann-Liouville integrals have been investigated ...
Kishin B. Sadarangani, Obidjon Kh. Abdullaev   +1 more
doaj   +1 more source

Reducing Entropy Generation in MHD Fluid Flow over Open Parallel Microchannels Embedded in a Micropatterned Permeable Surface

Entropy, 2013
The present study examines embedded open parallel microchannels within a micropatterned permeable surface for reducing entropy generation in MHD fluid flow in microscale systems.
Ishak Hashim, Kamaruzzaman Sopian, Mohammad H. Yazdi, Shahrir Abdullah   +3 more
doaj   +1 more source

YlmG1 is localized exclusively to the chloroplast envelope membrane and is involved in preprotein translocation in Arabidopsis thaliana

FEBS Open Bio, EarlyView.
Cytosolically synthesized chloroplast preproteins are translocated across the outer and inner envelope membranes through translocons called TOC and TIC, respectively. In green algae and plants, the TIC core is composed of essential membrane proteins, Tic12, Tic20, and Tic214.
Mengyi Li, Xueyang Zhao, Masato Nakai
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Existence and uniqueness for one-phase Stefan problems of non-classical heat equations with temperature boundary condition at a fixed face

Electronic Journal of Differential Equations, 2006
We prove the existence and uniqueness, local in time, of a solution for a one-phase Stefan problem of a non-classical heat equation for a semi-infinite material with temperature boundary condition at the fixed face.
Adriana C. Briozzo, Domingo A. Tarzia
doaj