Results 91 to 100 of about 4,856 (294)

DU BOIS COMPLEXES OF CONES OVER SINGULAR VARIETIES, LOCAL COHOMOLOGICAL DIMENSION, AND K-GROUPS

open access: yesRevue Roumaine Mathematiques Pures Appliquees
We compute the Du Bois complexes of abstract cones over singular varieties, and use this to describe the local cohomological dimension and the non-positive K-groups of such cones.
Popa, Mihnea, Shen, Wanchun
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

CR Singularities of Real Fourfolds in C3 [PDF]

open access: yes, 2009
CR singularities of real 4-submanifolds in complex 3-space are classified by using local holomorphic coordinate changes to transform the quadratic coefficients of the real analytic defining equation into a normal form.
Coffman, Adam
core  

Singularities of Plane Algebraic Curves [PDF]

open access: yes, 2021
Plane algebraic curves are defined as zeroes of polynomials in two variables over some given field. If a point on a plane algebraic curve has a unique tangent line passing through it, the point is called simple.
Härkönen, Robert Mattias
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Beyond the average: detecting global singular nodes from local features in complex networks

open access: yes, 2006
1 figure, 1 table, 5 pages. A working manuscript.
Costa, Luciano da F.   +2 more
openaire   +2 more sources

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

open access: yesFEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke   +4 more
wiley   +1 more source

Infinitesimal locally trivial deformation spaces of compact complex surfaces with ordinary singularities

open access: yesProceedings of the Japan Academy, Series A, Mathematical Sciences, 1999
To describe locally trivial infinitesimal deformations of a surface \(S\) with ordinary singularities the author computes \(H^1(S,\Theta_S)\) (where \(\Theta_S=\text{Hom}(\Omega^1_S,{\mathcal O}_S)\)) in terms of data on the normalisation. To keep track of the cuspidal and triple points he uses the \(2\)-cubic hyperresolution of \(S\) in the sense of [\
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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