Results 81 to 90 of about 4,856 (294)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Characteristics of geological evolution based on the multifractal singularity theory: A case study of Heyu granite and Mesozoic tectonics

Open Geosciences
Tectonic movement and magmatic activity are complex geological processes resulting from the interaction of multiple factors. These processes are often characterized by local singularities with nonlinear characteristics.
Dong Wenchao, Jiang Zhongfeng, Zhang Peixin, Zhang Yuchan, Liu Leyi   +4 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

On the Directionally Newton-non-degenerate Singularities of Complex Hypersurfaces [PDF]

, 2008
OWLF 2008We introduce a minimal generalization of Newton-non-degenerate singularities of hypersurfaces. Roughly speaking, an isolated hypersurface singularity is called directionally Newton-non-degenerate if the local embedded topological singularity ...
Kerner, Dmitry
core   +2 more sources

Bosonic near-CFT1 models from Fock-space fluxes

Journal of High Energy Physics
We construct a family of near-CFT1 models with a conserved U(1) charge, whose basic degrees of freedom are canonical bosons. The Sachdev-Ye-Kitaev (SYK) model — the first microscopic model that realizes the near-CFT1 dynamics — is based on random p-local
Yiyang Jia
doaj   +1 more source

O auto da compadecida: memory, identity and imaginary in intersemiotic translation

Revista Brasileira de Literatura Comparada, 2022
O Auto da Compadecida, a film directed by Guel Arraes, in 2000, is an intersemiotic translation of the dramatic text by Ariano Suassuna, produced in 1955.
Maria Auxiliadora Fontana Baseio, Marcos Julio Sergl, Lourdes Ana Pereira Silva   +2 more
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Two-dimensional Adaptive Analysis Based on Arbitrary Meshes and Its Optimization [PDF]

长江科学院院报
[Objective] This study aims to optimize the two-dimensional adaptive analysis strategy of the independent cover-based manifold method, focusing on addressing its deficiencies in error control and mesh distribution, thereby significantly enhancing ...
SONG Wen-shuo, SU Hai-dong, XIE Zhi-qiang
doaj   +1 more source

The Relationship among Complex Fractionated Electrograms, Wavebreak, Phase Singularity, and Local Dominant Frequency in Fibrillation Wave-Dynamics: a Modeling Comparison Study

Journal of Korean Medical Science, 2014
Although complex fractionated electrogram (CFE) is known to be a target for catheter ablation of fibrillation, its physiological meaning in fibrillation wave-dynamics remains to be clarified. We evaluated the spatiotemporal relationships among the parameters of fibrillation wave-dynamics by simulation modeling.
Yonghyeon Yun, Minki Hwang, Jae Hyung Park, Hangsik Shin, Eun Bo Shim, Hui-Nam Pak   +5 more
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source