Results 61 to 70 of about 4,856 (294)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
The Curvature Veronese Of A 3-manifold Immersed In Euclidean Space
, 2017 We study the behaviour of the curvature locus of a 3-manifold immersed in R-n, n >= 5, describing their possible topological types at the different points of a 3-manifold immersed in R-6.
M. Carmen +3 more
core +1 more source
Detection of Complex Salient Regions
EURASIP Journal on Advances in Signal Processing, 2008 The goal of interest point detectors is to find, in an unsupervised way, keypoints easy to extract and at the same time robust to image transformations. We present a novel set of saliency features based on image singularities that takes into account the ...
Petia Radeva +2 more
doaj +1 more source
FEBS Letters, EarlyView.We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace +6 more
wiley +1 more source
Pairs of geometric foliations of regular and singular surfaces [PDF]
, 2010 We examine some generic features of surfaces in the Euclidean 3-space $\mathbb{R}^3$ related to the Gauss map on the surface. We consider these features on smooth surfaces and on singular surfaces with a cross-cap singularity.
Oliver, Joseph Michael +1 more
core
Monodromy of real isolated singularities
, 2003 Complex conjugation on complex space permutes the level sets of a real polynomial function and induces involutions on level sets corresponding to real values.
A'Campo, Norbert
core +1 more source
Modular Hamiltonians for future-perturbed states
Journal of High Energy PhysicsWe develop a perturbative understanding of the modular Hamiltonian for a 2D CFT, divided into left and right half-spaces, with a weak local perturbation inserted in the future wedge.
Xiaole Jiang +3 more
doaj +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source