Results 41 to 50 of about 4,391 (253)

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Matrix quantum mechanics on S1/Z2

Nuclear Physics B, 2018
We study Matrix Quantum Mechanics on the Euclidean time orbifold S1/Z2. Upon Wick rotation to Lorentzian time and taking the double-scaling limit this theory provides a toy model for a big-bang/big crunch universe in two dimensional non-critical string ...
P. Betzios, U. Gürsoy, O. Papadoulaki
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

A rational optimal block hybrid method for enhanced accuracy in solving Lane–Emden equations

Partial Differential Equations in Applied Mathematics
This paper introduces a block hybrid method designed for the effective resolution of Lane–Emden equations, which are characterized as second-order boundary value problems incorporating a singularity at the origin.
Sandile Motsa, Salma Ahmedai, Mpho Nefale, Olumuyiwa Otegbeye   +3 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

FEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Modular Hamiltonians for future-perturbed states

Journal of High Energy Physics
We develop a perturbative understanding of the modular Hamiltonian for a 2D CFT, divided into left and right half-spaces, with a weak local perturbation inserted in the future wedge.
Xiaole Jiang, Daniel Kabat, Aakash Marthandan, Debajyoti Sarkar   +3 more
doaj   +1 more source

Infinite distance networks in field space and charge orbits

Journal of High Energy Physics, 2019
The Swampland Distance Conjecture proposes that approaching infinite distances in field space an infinite tower of states becomes exponentially light. We study this conjecture for the complex structure moduli space of Calabi-Yau manifolds.
Thomas W. Grimm, Chongchuo Li, Eran Palti   +2 more
doaj   +1 more source

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

Detection of Complex Salient Regions

EURASIP Journal on Advances in Signal Processing, 2008
The goal of interest point detectors is to find, in an unsupervised way, keypoints easy to extract and at the same time robust to image transformations. We present a novel set of saliency features based on image singularities that takes into account the ...
Petia Radeva, Oriol Pujol, Sergio Escalera   +2 more
doaj   +1 more source