Results 31 to 40 of about 4,391 (253)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Backreacting D-brane instantons on branes at singularities

Journal of High Energy Physics, 2017
Non-perturbative D-brane instanton effects in 4d N = 1 $$ \mathcal{N}=1 $$ string compactifications can be geometrized in terms of a backreacted generalized geometry. We extend earlier results to setups in which the D-brane instanton is charged under the
Eduardo García-Valdecasas Tenreiro, Angel Uranga   +1 more
doaj   +1 more source

Ganglionated plexi stimulation induces pulmonary vein triggers and promotes atrial arrhythmogenecity: In silico modeling study. [PDF]

PLoS ONE, 2017
BACKGROUND:The role of the autonomic nervous system (ANS) on atrial fibrillation (AF) is difficult to demonstrate in the intact human left atrium (LA) due to technical limitations of the current electrophysiological mapping technique.
Minki Hwang, Byounghyun Lim, Jun-Seop Song, Hee Tae Yu, Ah-Jin Ryu, Young-Seon Lee, Boyoung Joung, Eun Bo Shim, Hui-Nam Pak   +8 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Identifying access barriers faced by rural and dispersed communities to better address their needs: implications and lessons learned for rural proofing for health in the Americas and beyond

Rural and Remote Health, 2023
Introduction: Universal access to health services and universal health coverage are needed to achieve good health for all, yet rural communities face a variety of access barriers.
Natalia Houghton, Ernesto Bascolo, Rachael Cohen , Norma Lleny Cruz Vilcarromero, Hernán Rodriguez Gonzalez, Daniel Albrecht, Theadora Koller, James Fitzgerald   +7 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Robust Damage Detection and Localization Under Complex Environmental Conditions Using Singular Value Decomposition-based Feature Extraction and One-dimensional Convolutional Neural Network

Chinese Journal of Mechanical Engineering, 2023
Abstract Ultrasonic guided wave is an attractive monitoring technique for large-scale structures but is vulnerable to changes in environmental and operational conditions (EOC), which are inevitable in the normal inspection of civil and mechanical structures.
Shengkang Zong, Sheng Wang, Zhitao Luo, Xinkai Wu, Hui Zhang, Zhonghua Ni   +5 more
openaire   +2 more sources

The Huerta Agricultural Landscape in the Spanish Mediterranean Arc: One Landscape, Two Perspectives, Three Specific Huertas

Land, 2020
The Huerta is recognised as one of the 13 specific agricultural landscapes in Europe, present in only three Mediterranean countries, namely Spain, Italy, and Greece.
Pablo Martí, Clara García-Mayor
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source