Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Inverse design in quantum nanophotonics: combining local-density-of-states and deep learning. [PDF]
Nanophotonics, 2023 Liu GX +6 more
europepmc +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
An efficient local outlier detection approach using kernel density estimation
Franklin OpenIn recent times, outlier detection has played a crucial role in computer networks, fraud detection, and many such applications. Despite adequate research initiatives addressing the topic of finding outliers in datasets, still faces numerous obstacles in ...
Rakhi +2 more
doaj +1 more source
Maximum electromagnetic local density of states via material structuring. [PDF]
Nanophotonics, 2023 Chao P +3 more
europepmc +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
Optimal Density for Municipal Revenues [PDF]
The distribution of lot sizes and associated improvements affect property values. Hence, zoning affects municipal property tax revenues. If optimal lot size is inconsistent with the targeted zoning density in a community, municipal revenue can be ...
Adelaja, Adesoji O., Chaudhuri, Malika
core
A novel bidirectional clustering algorithm based on local density. [PDF]
Sci Rep, 2021 Lyu B, Wu W, Hu Z.
europepmc +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Meta-Local Density Functionals: A New Rung on Jacob's Ladder. [PDF]
J Chem Theory Comput, 2021 Lehtola S, Marques MAL.
europepmc +1 more source