Results 131 to 140 of about 9,654,838 (253)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Nuclear speed and cycle length co-vary with local density during syncytial blastoderm formation in a cricket. [PDF]

Nat Commun, 2022
Donoughe S, Hoffmann J, Nakamura T, Rycroft CH, Extavour CG.   +4 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

CLoNe: automated clustering based on local density neighborhoods for application to biomolecular structural ensembles. [PDF]

Bioinformatics, 2021
Träger S, Tamò G, Aydin D, Fonti G, Audagnotto M, Dal Peraro M.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Isoseparation and robustness in finite parameter Bayesian inference [PDF]

, 2007
Under a new family of separations the distance between two posterior densities is the same as the distance between their prior densities whatever the observed likelihood when that likelihood is strictly positive.
Smith, J. Q., Rigat, Fabio
core  

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Exchange energy and potential using the Laplacian of the density

, 2012
The challenge of density functional theory is the useful approximation of the exchange - correlation energy. This energy can be approximated with the local electron density and the gradient of the density.
Wagner, Christopher E.
core  

Bye-bye, Local-in-matter-density Bias: The Statistics of the Halo Field Are Poorly Determined by the Local Mass Density

The Astrophysical Journal Letters
Bias models relating the dark matter field to the spatial distribution of halos are widely used in current cosmological analyses. Many models predict halos purely from the local Eulerian matter density, yet bias models in perturbation theory require ...
Deaglan J. Bartlett, Matthew Ho, Benjamin D. Wandelt   +2 more
doaj   +1 more source

Engineering of the Photon Local Density of States: Strong Inhibition of Spontaneous Emission near the Resonant and High-Refractive Index Dielectric Nano-objects. [PDF]

J Phys Chem C Nanomater Interfaces, 2022
Muravitskaya A, Movsesyan A, Guzatov DV, Baudrion AL, Adam PM, Gaponenko SV, Vincent R.   +6 more
europepmc   +1 more source