Results 71 to 80 of about 3,027,964 (314)

Local Authorities and Economic Development in Scotland - Report for the Convention of Scottish Local Authorities [PDF]

open access: yes, 1992
This report was commissioned by COSLA to identify the breadth, scale and importance of Scottish local authorities' activities in the field of economic ...
McQuaid, Ronald
core  

Inter-American Development Bank Cultural Center Annual Report 2009

open access: yes, 2010
This report summarizes the activities of the IDB Cultural Center in 2009. Throughout 2009, the IDB Cultural Center emphasized the Bank\u27s four priority areas (water, energy, education, and Opportunities for the Majority) among its own cultural ...
Inter-American Development Bank
core   +1 more source

USP7 promotes temozolomide resistance by stabilizing MGMT in glioblastoma

open access: yesCell Death and Disease
Glioblastoma (GBM), a World Health Organization (WHO) grade IV glioma, is one of the most lethal brain tumors, with a poor prognosis and limited treatment options.
Jiabing Li   +14 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

KCTD1 stabilizes c-Myc to upregulate PD-L1 and suppress anti-tumor immunity in hepatocellular carcinoma

open access: yesCell Death Discovery
Hepatocellular carcinoma (HCC) is the predominant histologic subtype of primary liver cancer and accounts for approximately 90% of cases worldwide.
Dongmei Zhong   +11 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Inter-American Development Bank Cultural Center Annual Report 1999

open access: yes, 1999
The IDB Cultural Center ended 1999 with a successful balance of diverse programs. Throughout the year, the IDB Cultural Center produced 32 events, including art exhibitions, concerts, music workshops and lectures.
Inter-American Development Bank
core   +1 more source

Regulatory role of non-coding RNA in ginseng rusty root symptom tissue

open access: yesScientific Reports, 2021
Ginseng rusty root symptom (GRS) is one of the primary diseases of ginseng. It leads to a severe decline in the quality of ginseng and significantly affects the ginseng industry.
Xingbo Bian   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

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