Results 151 to 160 of about 885,184 (197)
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Local drug delivery to the brain
Advanced Drug Delivery Reviews, 2002The controlled local delivery of antineoplastic agents by biodegradable polymers is a technique that allows for exposure of tumor cells to therapeutic doses of an active agent for prolonged periods of time while avoiding high systemic doses associated with debilitating toxicities.
Henry Brem
exaly +3 more sources
Prospection of Microfluidics for Local Drug Delivery
Current Drug Targets, 2022Abstract: Significant endeavors can be made to develop effective drug delivery systems. Nowa-days, many of these novel systems have gained attention as they focus primarily on increasing the bioavailability and bioaccessibility of several drugs to finally minimize the side effects, thus im-proving the treatment's efficacy.
Nimbagal R, Naveen +4 more
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Recrystallization of Adenosine for Localized Drug Delivery
Molecular Pharmaceutics, 2022Adenosine (ADO) is an endogenous metabolite with immense potential to be repurposed as an immunomodulatory therapeutic, as preclinical studies have demonstrated in models of epilepsy, acute respiratory distress syndrome, and traumatic brain injury, among others.
Ketki Y. Velankar +6 more
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Current Opinion in Oncology, 2000
Intensive research efforts are now focused on the development of new strategies for more effective delivery of drugs to the central nervous system. These strategies include chemical modification of drugs, disruption of the blood-brain barrier, and utilization of alternative routes for drug delivery.
R I, Haroun, H, Brem
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Intensive research efforts are now focused on the development of new strategies for more effective delivery of drugs to the central nervous system. These strategies include chemical modification of drugs, disruption of the blood-brain barrier, and utilization of alternative routes for drug delivery.
R I, Haroun, H, Brem
openaire +2 more sources
Otolaryngologic Clinics of North America, 2009
Topical drug delivery for sinonasal disorders is influenced by a variety of factors. Macroscopically (or anatomically), the ability of the drug to reach the appropriate region of the paranasal system is paramount. Delivery techniques, surgical state of the sinus cavity, delivery device, and fluid dynamics (volume, pressure, position) have a significant
Richard J, Harvey, Rodney J, Schlosser
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Topical drug delivery for sinonasal disorders is influenced by a variety of factors. Macroscopically (or anatomically), the ability of the drug to reach the appropriate region of the paranasal system is paramount. Delivery techniques, surgical state of the sinus cavity, delivery device, and fluid dynamics (volume, pressure, position) have a significant
Richard J, Harvey, Rodney J, Schlosser
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Optimizing drugs for local delivery
Drug News & Perspectives, 2009An international panel of speakers together with approximately 70 delegates were brought together by The Society for Medicines Research's symposium on Optimising Drugs for Local Delivery, held on June 11, 2009 at the Novartis Institutes for Biomedical Research, Horsham, UK.
Collingwood, S., Lock, R., Searcey, Mark
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Local drug delivery: Current applications
Progress in Cardiovascular Diseases, 1997Catheter-based treatment of coronary artery disease has historically been based on expansion or ablating vessels. Only in the last 3 years have we had devices that allow us to choose the location to apply agents directly onto or into the arterial wall. Previous trials of pharmaceutical agents in humans have failed despite animal trials showing efficacy.
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Recent Advances in Bioelectronics for Localized Drug Delivery
Small Methods, 2023AbstractThe last decade has witnessed remarkable advancements in bioelectronics, ushering in a new era of wearable and implantable devices for drug delivery. By utilizing miniaturized system design and/or flexible materials, bioelectronics illustrates ideal integration with target organs and tissues, making them ideal platforms for localized drug ...
Xinran Jiang +5 more
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Ultrasound Mediated Localized Drug Delivery
2011Chemotherapy is one of the frontline treatments for cancer patients, but the toxic side effects limit its effectiveness and potential. The goal of drug delivery is to reduce these side effects by encapsulating the drugs in a carrier which prevents release and can circulate throughout the body causing minimal damage to the healthy tissue.
Stuart, Ibsen +3 more
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Local drug delivery to composite tissue allografts
Microsurgery, 2000Unlike visceral solid-organ transplants, composite tissue allografts (CTA) are modules composed of various tissues, each with differing antigenicity, and therefore differing potential for rejection.1 Skin and muscle (and perhaps synovium) are the most antigenic and appear to be most susceptible to rejection, while bone, tendon, cartilage, and ...
S A, Gruber +4 more
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