Results 161 to 170 of about 885,184 (197)

Multicompartment Hydrogels for the Local Delivery of Chemotherapic Drugs

2019
Over 85% of human cancers are solid tumors. The effectiveness of anticancer therapy in solid tumors depends on adequate delivery of the therapeutic agent to tumor cells. Inadequate delivery would result in residual tumor cells, which in turn would lead to regrowth of tumors and possibly development of resistant cells. The most prominent option, for now,
Boi S., Dellacasa E., Rouatbi N., Monticelli O., Pastorino L.   +4 more
openaire   +3 more sources

Microdialysis: A system for localized drug delivery into the brain

Brain Research Bulletin, 1989
To determine why intrahypothalamic microinjections of pyrogen-free saline (PFS) often induce core temperature (Tco) rises, guide cannulas were implanted bilaterally into the preoptic-anterior hypothalamus (POA) of guinea pigs; 1 week later, injectors were inserted to 1 mm beyond the guides and either no injection or 1 microliter PFS was administered ...
N, Quan, C M, Blatteis
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Local drug delivery for percutaneous coronary intervention

Pharmacology & Therapeutics, 2011
Since the first successful coronary angioplasty by Andreas Grüntzig in 1977, the field of percutaneous coronary intervention (PCI) has expanded rapidly. Rapid technological refinement has seen equipment and complementary pharmacotherapy to improve the outcome of PCI evolve dramatically, driven by clinical need and enormous market forces.
S, Sharma, C, Christopoulos, N, Kukreja, D A, Gorog   +3 more
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Local drug and gene delivery through microbubbles

Progress in Cardiovascular Diseases, 2001
Ultrasound contrast agents (microbubbles) lower the threshold for cavitation by ultrasound energy. Ultrasound microbubbles may be used as cavitation nuclei for drug and gene delivery. By tailoring the physical properties of microbubbles and coating materials, drugs and genetic drugs can be incorporated into ultrasound contrast agents.
E C, Unger, E, Hersh, M, Vannan, T O, Matsunaga, T, McCreery   +4 more
openaire   +2 more sources

Local drug delivery in recurrent malignant gliomas

Neurological Sciences, 2005
In recurrent malignant gliomas, we scheduled a protocol by adding to systemic temozolomide a local treatment delivered through a reservoire positioned in the surgically created cavity, consisting of either mitoxantrone, liposome-loaded doxorubicine or nimustine (ACNU). The progression-free survival (PFS) and survival time (ST) of the whole group of 112
Boiardi, A., Eoli, M., Salmaggi, A., Lamperti, E., Botturi, A., Solari, A., Di Meco, F., Broggi, G., Silvani, A.   +8 more
openaire   +3 more sources

Local Delivery of Antirestenotic Drugs

1999
In the past several years, percutaneous catheter-based techniques have been used with increasing frequency to relieve symptomatic narrowing of the coronary arteries.1,2Yet, despite advances in catheter technology and surgical technique, initial procedural success is still limited by acute thrombosis in 5% or clinical restenosis within six months in 30 ...
Douglas E. Drachman, Elazer R. Edelman, Campbell Rogers   +2 more
openaire   +1 more source

Localized targeted antiangiogenic drug delivery for glioblastoma

Journal of Neuro-Oncology, 2018
Systemic delivery of antiangiogenic agents has been ineffective in improving the overall survival of patients with both primary and recurrent glioblastoma, in part due to dose-limiting toxicities. With the development of new and efficient localized delivery methods and vehicles, an otherwise lethal dose of antiangiogenic chemotherapy can be used to ...
Gregory D, Arnone, Abhiraj D, Bhimani, Tania, Aguilar, Ankit I, Mehta   +3 more
openaire   +2 more sources

Periodontal Disease Treatment by Local Drug Delivery

Journal of Periodontology, 1985
The subgingival microbiologic composition of diseased periodontal sites was evaluated by darkfield microscopy before and after scaling or local delivery of tetracycline. A standardized sampling and counting method using a crevicular washing technique was developed to determine both numbers and proportions of morphotypes using darkfield microscopy ...
J M, Goodson, S, Offenbacher, D H, Farr, P E, Hogan   +3 more
openaire   +2 more sources

Rationale for local drug delivery.

Seminars in interventional cardiology : SIIC, 1998
Although advances during the last decade have transformed the management of coronary artery disease, deficiencies in our understanding of the basic processes of arterial thrombosis and restenosis after percutaneous intervention continue to present major challenges to their prevention.
D S, Eccleston, M C, Horrigan, S G, Ellis   +2 more
openaire   +1 more source

Local drug delivery

Catheterization and Cardiovascular Diagnosis, 1997
C R, Lambert, E, Camenzind, K, Robinson
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