Results 111 to 120 of about 1,563,028 (315)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Need to Know Review Number two: What Local Government Needs to Know about Public Health [PDF]
, 2014 This review of existing research on local government and public health focuses on the leadership role of local government in developing local public health systems that are capable of addressing the wider determinants of ...
South, J, Hunter, DJ, Gamsu, M
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Local Food Impacts on Health and Nutrition [PDF]
Prevalence of local foods is believed to answer several food issues one of which is health and nutrition. This study focused on the on the availability of local foods to consumers and see its relationship with two specific diet-related diseases namely ...
Ramirez, Octavio A. +3 more
core +1 more source
Barriers and enablers of local adaptive measures : a case study of Bengaluru’s informal settlement [PDF]
, 2018 This paper highlights the barriers and enablers to climate change-related adaptation experienced in some of Bengaluru’s informal settlements. The barriers described in the paper include economic, social, governance and information related issues that ...
Michael, Kavya +2 more
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A comparative perspective on self-assessment of Local Agenda 21 in European cities [PDF]
, 2004 The aim of this article is to describe a model for evaluating Local Agenda 21 processes. The local level extension of Agenda 21, Local Agenda 21 (LA21), is a typical instrument for extensive governance.
Joas, M., Grönholm, B.
core +1 more source
Molecular Oncology, EarlyView.Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata +10 more
wiley +1 more source
Public involvement in Local Agenda 21 : the impact of local authority policy processes [PDF]
, 2002 The signing of Agenda 21 by the UK government committed local authorities in England to drawing up local action plans for sustainable development in partnership with their citizens.
Connelly, Stephen
core
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source