Results 101 to 110 of about 1,555,406 (315)
Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis
Molecular Oncology, EarlyView.LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini +1 more
wiley +1 more source
Made in conflict. Local residents' construction of a local environmental problem
, 2011 The aim of this paper is to understand how local residents participate in the construction of local environmental problems and to evaluate a particular analytical approach in environmental sociology to study this phenomenon.
Karin Gustafsson, Gustafsson, Karin,
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Olympic stadiums in their urban environment: A question of design and cultural significance.
, 2012 peer reviewedThe article analyses the relationship between Olympic stadiums and the urban environment. This relationship is considered as key to understanding the cultural significance of these exceptional event-based buildings.
Kiuri, Miranda +3 more
core +1 more source
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Barriers and enablers of local adaptive measures : a case study of Bengaluru’s informal settlement [PDF]
, 2018 This paper highlights the barriers and enablers to climate change-related adaptation experienced in some of Bengaluru’s informal settlements. The barriers described in the paper include economic, social, governance and information related issues that ...
Michael, Kavya +2 more
core
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Public involvement in Local Agenda 21 : the impact of local authority policy processes [PDF]
, 2002 The signing of Agenda 21 by the UK government committed local authorities in England to drawing up local action plans for sustainable development in partnership with their citizens.
Connelly, Stephen
core
, 2014 The engagement of UK local authorities is vital if national government is to meet its climate change commitments. However, with no mandatory targets at local government level, other drivers must explain engagement. Using a Geographic Information System,
Mann, Sarah +2 more
core +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source