Results 81 to 90 of about 1,555,406 (315)

Children's perspectives on playground use as basis for children's participation in local play space management

, 2015
Implementing children’s perspectives into playground management could be a way of improving play possibilities for children in the local public space and supporting sustainable development, but it requires adults’ understanding.
Sveriges lantbruksuniversitet., Jansson, Märit,   +1 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Les écoles, de nouvelles aménités urbaines aux États-Unis ?

Revue Internationale d’Éducation de Sèvres
After decades of segregation followed by desegregation efforts, schools have become the subject of renewed interest in the United States over the last fifty years, and are viewed as an urban amenity with the potential to retain and attract new households
Nora Nafaa, Magda Maaoui
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Empowering local governments to make a disaster resilient built environment within Sri Lankan Cities

, 2013
Urban areas are growing very rapidly all over the world, particularly in developing countries. As a result of rapid urbanisation, the world’s population is increasingly concentrated in large cities leading to unplanned urban development with ...
Amaratunga, Dilanthi, Haigh, Richard, Malalgoda, Chamindi   +2 more
core  

Devolving power from the state : local initiatives for nature protection and recreation in Sweden

, 2020
Quests for devolving more power to local actors for nature protection stem from both international and national policies. Also, there is a growing recognition of the need for local governments to promote green infrastructure for citizens to recreate and ...
Mancheva, Irina, Eckerberg, Katarina, Mancheva, Irina,, Bjärstig, Therese,, Miljand, Matilda, Bjärstig, Therese, Eckerberg, Katarina,, Miljand, Matilda,   +7 more
core   +1 more source

Local Vulnerability Factors Can Be Used as an Innovative Approach for Developing Inclusive Urban Community Flood Resilience Policies

Journal of Flood Risk Management
Rapid urbanisation has resulted in the sealing of pervious surfaces and the construction of houses in flood‐vulnerable areas, aggravating urban flooding.
Connie Susilawati, Bernadetta Devi, Farida Rachmawati, Ria Aryani Soemitro, Melissa Teo, Ashantha Goonetilleke, Sara Wilkinson   +6 more
doaj   +1 more source

Un village du Hubei au miroir des disparités spatiales de l’offre scolaire chinoise

Revue Internationale d’Éducation de Sèvres
Like many countries, China has an unequal education system, even though all children attend school. This inequality of opportunity is officially reflected in the existence of “key schools”, very recently named “quality schools”.
Zhang Chen, Franck Chignier-Riboulon
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source