Results 141 to 150 of about 1,555,406 (315)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

‘Local Food’ Systems in County Durham: The capacities of community initiatives and local food businesses to build a more resilient local food system [PDF]

, 2011
This thesis provides a critical assessment of the capacities of ‘local food’ businesses and community-led local food initiatives - in County Durham, North East England - to build resilience into our food systems.
MYCOCK, AMY,ELIZABETH
core  

A Multicriteria Analysis to Integrate Stakeholder Perceptions of Ecosystem-Based Flood Adaptations in Coastal Urban Areas

Documents d'Anàlisi Geogràfica
Inland and coastal floods are becoming more frequent and severe, affecting natural and socioeconomic systems. Local adaptation to climate change involves complex decisions which benefit from the integration of opinions from different stakeholders in the
Mar Riera-Spiegelhalder, Luís Campos Rodrigues, Adrián Ferrandis Martínez   +2 more
doaj   +1 more source

Structural variation and introgression from wild populations in East Asian cattle genomes confer adaptation to local environment. [PDF]

Genome Biol, 2023
Xia X, Zhang F, Li S, Luo X, Peng L, Dong Z, Pausch H, Leonard AS, Crysnanto D, Wang S, Tong B, Lenstra JA, Han J, Li F, Xu T, Gu L, Jin L, Dang R, Huang Y, Lan X, Ren G, Wang Y, Gao Y, Ma Z, Cheng H, Ma Y, Chen H, Pang W, Lei C, Chen N.   +29 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Need to Know Review Number two: What Local Government Needs to Know about Public Health

, 2014
This review of existing research on local government and public health focuses on the leadership role of local government in developing local public health systems that are capable of addressing the wider determinants of ...
South, J, Hunter, DJ, Gamsu, M
core  

Rhizosphere microbial community assembly and association networks strongly differ based on vegetation type at a local environment scale. [PDF]

Front Microbiol, 2023
Liu L, Ma L, Zhu M, Liu B, Liu X, Shi Y.
europepmc   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Ca Cations Impact the Local Environment inside HZSM-5 Pores during the Methanol-to-Hydrocarbons Reaction. [PDF]

ACS Catal, 2023
Liutkova A, Zhang H, Simons JFM, Mezari B, Mirolo M, Garcia GA, Hensen EJM, Kosinov N.   +7 more
europepmc   +1 more source