Results 151 to 160 of about 6,425,933 (304)

CURRENT TRENDS IN THE SURGICAL MANAGEMENT OF RECTAL CANCER: FROM LOCAL EXCISION TO TOTAL MESORECTAL EXCISION

<p><span><em><span>Rectal cancer remains a significant public health concern with its management involving surgery playing a crucial role. In recent years, the surgical approach to rectal cancer has undergone significant evolution,
Аlimova Zulayho Quvondiqovna, Sherbekov Ulugbek Akhrorovich   +1 more
core   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank

FEBS Open Bio, EarlyView.
Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer, Pawel Rubach, Zbigniew Dauter, Wojciech Dec, Dariusz Brzezinski, Marta Kulik, Wladek Minor, Mariusz Jaskolski   +7 more
wiley   +1 more source

What Is the Best Next Step After Local Excision of High-Risk T1–T2N0 Rectal Cancer? A Systematic Review and Network Meta-Analysis

Among early rectal adenocarcinoma (pathologic high-risk T1 or T2N0 without mets) initially managed by local excision, compare post-excision strategies (Completion TME/ISR/APR, Adjuvant CRT, Observation) for oncologic outcomes (local recurrence, DFS, OS)
Ekkarin Supatrakul, Rangsima Thiengthiantham, Kullawat Bhatanaprabhabhan, Pawit Sutharat, Thanat Tantinam, Nataphon Santrakul, Suradet buakhrun, Boonchai Ngamsirimas, Punnawat Chandrachamnong, Suwan Sanmee   +9 more
core  

Rapidly Progressive Buschke-Löwenstein Tumor Managed With Wide Local Excision and Healing by Secondary Intention: A Case Report and Literature Review. [PDF]

Case Rep Surg
Chin SE, Castro NR, Lujan HJ.
europepmc   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Supplemental Data - Supplementary Table II for JAAD Review article "Mohs micrographic surgery versus wide local excision for treatment of trichilemmal carcinoma: a systematic review"

Analysis of risk factors for trichilemmal carcinoma recurrence after wide local ...
Liakos, Will
core   +1 more source

Mesh reconstruction of the myopectineal region following wide local excision for inguinofemoral tumors. [PDF]

J Abdom Wall Surg
George PY, Stephen PT, Titus DK, Roopavathana B, Ambrose NP, Joseph P, Chase S.   +6 more
europepmc   +1 more source

Genetic dissection of human ABCE1 in yeast reveals separable requirements for ribosome recycling and suppression of aberrant reinitiation

FEBS Open Bio, EarlyView.
Human ABCE1 cannot functionally replace its yeast ortholog. Yeast–human chimera analysis identified NBD1 as a major interspecies barrier. Genetic screening yielded hABCE1 revertants that rescue yeast viability but fail to suppress aberrant translation reinitiation in the 3′ UTR.
Eriko Nakata, Yuxin Li, Kei Endo, Koichi Ito   +3 more
wiley   +1 more source

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

FEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa, Mohammed Nooh, Akhil Geddati, Alex Dopico, Anna N. Bukiya   +4 more
wiley   +1 more source