Results 71 to 80 of about 6,699,757 (251)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

The Fractional OU Process: Term Structure Theory and Application [PDF]

The paper revisits dynamic term structure models (DTSMs) and proposes a new way in dealing with the limitation of the classical affine models. In particular, this paper expands the flexibility of the DTSMs by applying a fractional Brownian motion as the ...
Esben Hoeg, Per Frederiksen
core  

Fractional thermal diffusion and the heat equation

Open Physics, 2015
Fractional calculus is the branch of mathematical analysis that deals with operators interpreted as derivatives and integrals of non-integer order. This mathematical representation is used in the description of non-local behaviors and anomalous complex ...
Gómez Francisco, Morales Luis, González Mario, Alvarado Victor, López Guadalupe   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Fractional Ornstein-Uhlenbeck Process: Term Structure Theory and Application [PDF]

The paper revisits dynamic term structure models (DTSMs) and proposes a new way in dealing with the limitation of the classical affine models. In particular, this paper expands the flexibility of the DTSMs by applying a fractional Brownian motion as the ...
Frederiksen, Per H., Høg, Espen P.
core  

Input-output linearization and fractional robust control of a non-linear system [PDF]

, 2001
This article deals with the association of a linear robust controller and an input-output linearization feedback for the control of a perturbed and non-linear system.
Oustaloup, Alain, Pommier-Budinger, Valérie, Jocelyn Sabatier, Patrick Lanusse, Lanusse, Patrick, Valerie Pommier, Sabatier, Jocelyn, Alain Oustaloup   +7 more
core   +1 more source

Closed form solutions of two time fractional nonlinear wave equations

Results in Physics, 2018
In this article, we investigate the exact traveling wave solutions of two nonlinear time fractional wave equations. The fractional derivatives are described in the sense of conformable fractional derivatives. In addition, the traveling wave solutions are
M. Ali Akbar, Norhashidah Hj. Mohd. Ali, Ripan Roy   +2 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Effect of local fractional derivatives on Riemann curvature tensor

Examples and Counterexamples
In this paper, we give a main example indicating the ineffectiveness of the local fractional derivatives on the Riemann curvature tensor that is a common tool in calculating curvature of a Riemannian manifold. For this, first we introduce a general local
Muhittin Evren Aydin
doaj   +1 more source

Mathematical Modeling of Linear Fractional Oscillators

Mathematics, 2020
In this work, based on Newton’s second law, taking into account heredity, an equation is derived for a linear hereditary oscillator (LHO). Then, by choosing a power-law memory function, the transition to a model equation with Gerasimov–Caputo fractional ...
Roman Parovik
doaj   +1 more source