Results 91 to 100 of about 193,471 (315)

Towards a UK local government reform Act of 2015: improving public sector performance for 2025

, 2013
This paper proposes a three tiered governance structure to rebalance local government within the United Kingdom. The introduction of a North of England assembly is proposed to rebalance the North / South divide.
Khan, Nadeem, Korac-Kakabadse, Nada, Khan, N, Kakabadse, Nada K   +3 more
core  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Urban Local Governance in the Crucible: empirical overtones of central government meddling in local urban councils affairs in Zimbabwe [PDF]

This article explores the criticalness of decentralized governance as a solution towards service delivery challenges experienced by urban centres.
Jonga WELLINGTON, Chirisa INNOCENT
core  

Local Governance in Developing Countries

, 2006
This book develops a comparative institutional framework for responsive, responsible, and accountable governance in developing countries. It provides a synthesis of analytical literature on local governance.
Shah, Anwar
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Local Governance and Community Action: How poor and marginalized people can achieve change [PDF]

, 2012
Most people experience the impacts of governance, fair or unfair, at a very local level. It is where poor and marginalized people, including women, experience inequalities most keenly – in the way that issues that particularly concern them tend to get de-
Rowlands, Jo
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Transboundary Water Governance in the Kabul River Basin: Implementing Environmental and Public Diplomacy Between Pakistan and Afghanistan

, 2019
This research highlights the outcomes of the environmental diplomacy workshop held between members of civil society from Afghanistan and Pakistan on water cooperation in the Kabul River Basin, one of the most heavily conflicted transboundary river basins
Sgorbati, Susan, Halasah, Suleiman, Zia, Asim, Panikkar, Bindu, Cohen, Michael, Rice, Diana, Ali, Shaukat, Salimee, Naeem, Ryan, Benjamin, Hameed, Kashif, Aman, Zuhra, Ahmad, Monir, Fayyaz, Muhammad, Del Rossi, Gemma, Abid, Muhammand, Hashimi, Nadia, Hussain, Mujahid   +16 more
core   +1 more source

Urban governance arrangements for sustainability and justice – linking theory with experience

Urban Transformations
The Leipzig Charter highlights the need for integrated, place-based participatory governance approaches to achieve more sustainable and just urban futures. In this article, we provide a synthesis of our transdisciplinary analysis of ten EU projects which
Jakob Kramer, Sophia Silverton, Philipp Späth   +2 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source