Results 111 to 120 of about 193,471 (315)

Land use management as a challenge for local governance

, 2021
szabadon elérhető / Open accessNew Challenges of Local Governance in Times of Uncertainty and Complexity.
Farkas, Jenő Zsolt, Hardi, Tamás, Kovács, András Donát   +2 more
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Assessing open governance data in South Cotabato [PDF]

, 2014
The Province of South Cotabato is located in the southern part of the Philippines with a long tradition of participatory governance processes. The impact of providing information to citizens through the government website is still very low at this stage.

core  

Specimen sharing for epidemic preparedness: Building a virtual biorepository system from local governance to global partnerships. [PDF]

PLOS Glob Public Health, 2023
Giri J, Pezzi L, Cachay R, Gèlvez Ramirez RM, Tami A, Bethencourt S, Lozano A, Gotuzzo Herencia JE, Poje J, Jaenisch T, Chu M.   +10 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Europeanisation of the Urban Level: Evaluating the Impact of the EU on Local Governance in Britain [PDF]

, 2004
EU initiatives provide urban institutions and actors across Europe with new and unprecedented access to information, legitimacy, and not least, financial support.
Marshall, Adam.
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Local Governance in Western Europe

, 2001
Book synopsis: `Its strength lies in combining theoretical insights with an impressive range of empirical material. The analysis is subtle and multi-layered....
John, P C., John, Peter
core  

Distinctive transnational city-to-city partnerships, decentralization, and local governance of China as a Global East Country. [PDF]

PLoS One, 2023
Xu J, Liu H, Huang G.
europepmc   +1 more source

Local Governments Debt

, 2016
[Excerpt] In the public sector, debt results when public organizations borrow money from an individual or another organization with the promise of repayment at a later date (Mikesell 2013).
openaire   +2 more sources