Results 31 to 40 of about 2,744 (274)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Labour Governments and the docks 1945-51: international and industrial tension [PDF]
, 1994 This account of the 1945-51 Governments emphasises the extent to which its two principle tasks - economic recovery and the containment of communism - coloured its approach to events in the docks.
Phillips, James K.
core
Universal Access to Antiretroviral Therapy in Thailand: An Analysis of the Policy Process [PDF]
Antiretroviral therapy (ART) is effective in reducing HIV morbidity and mortality as well as improving patients' quality of life. However, because of several hurdles, resource-poor countries have provided treatment to only a few people in need.
Tantivess, Sripen
core +1 more source
THE DEVELOPMENT OF CULTURAL SECTOR IN THE RURAL TERRITORIES OF THE REPUBLIC OF CRIMEA: DEVELOPMENT PRIORITIES CHOICE [PDF]
Krymskij Naučnyj Vestnik, 2016 The optimization of demand pattern in cultural sector is one of the most important government’s tasks. Federal authorities, society, local authorities, several individual, enterprises, social organizations and mass media have an opportunity to influence ...
Olga Pernatskaia
doaj
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Ethical Concerns of School Closures for Low-Income School Aged Children
Voices in Bioethics, 2020 Photo by Jeremy Alford on Unsplash INTRODUCTION COVID-19 is the latest threat to educational equity.1 The use of technology for work, school, and social interaction has increased for many Americans yet not all have access to technology necessary to ...
Shami-Iyabo Mitchell
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Performance of public tasks by companies of local government units
Central European Review of Economics & Finance, 2017 The present article focuses on the issue of the provision of services of general economic interest by companies of local government units. Various parts discuss the basic requirements for entrusting the provision of this type of services to commercial companies, with particular reference to phenomena observed on a practical basis. It also addresses the
openaire +2 more sources