Results 31 to 40 of about 553,059 (265)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Engaging the local government in research & extension: The ACIAR-ICM-landcare experience
Annals of Tropical Research, 2017 Agricultural research and extension are important elements for improving agricultural production and food systems. It is said that the enhancement of traditional farming into science-based agriculture requires expeditious transfer of research results ...
Evy Elago-Carusos +2 more
doaj +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
Exploring circularity in African cities: barriers and opportunities for meaningful action
Environmental Research: Infrastructure and SustainabilityAs African cities are on the frontline of a poly-crisis (Allouche et al 2023), the need for local action becomes more apparent. Local government authorities (LGAs) are uniquely positioned as crucial actors to address resource security, climate change ...
Zakiyya Atkins +3 more
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
A Decade of improvement for local government
Commonwealth Journal of Local Governance, 2010 The theme of this year’s Commonwealth Local Government Conference was Improving local government: the Commonwealth vision. This theme is fundamental to all of us working in and with local government, but particularly so in the current economic climate ...
Susan Rhodes
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
Unlocking value: a comprehensive costing study of primary health care service delivery in Tanzania
BMC Primary CareBackground Tanzania has long prioritized primary health care (PHC) as the pathway to achieving universal health coverage. However, greater, and more effective investments are needed to expand access to quality PHC services and further improve population ...
Federica Margini +8 more
doaj +1 more source
Review of the Commonwealth Local Government Good Practice Scheme
Commonwealth Journal of Local Governance, 2012 The overarching objective of the Commonwealth Local Government Good Practice Scheme (GPS) was to contribute towards the achievement of the Millennium Development Goals at the local level; there were four expected outputs: 1.
Rachael Duchnowski
doaj +1 more source