Results 41 to 50 of about 579,379 (266)
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Success, challenges and prospects of decentralization in Africa: a systematic review
Cogent Social SciencesDecentralization remains a global development approach. African countries have been using decentralization by devolution to realize their development vision. This study assesses the success, challenges, and prospects of decentralization in Africa.
Rogers Rugeiyamu, Adam Msendo
doaj +1 more source
The Municipalities and INSPIRE – Any Connection?
Geoforum Perspektiv, 2014 On the surface, the municipalities are neither data owners nor data systems managers in connection with Denmark's reporting of data to INSPIRE. However, if you dig a little deeper in the actual data reports, you will see that the municipalities are ...
Inge Flensted
doaj +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
Engaging the local government in research & extension: The ACIAR-ICM-landcare experience
Annals of Tropical Research, 2017 Agricultural research and extension are important elements for improving agricultural production and food systems. It is said that the enhancement of traditional farming into science-based agriculture requires expeditious transfer of research results ...
Evy Elago-Carusos +2 more
doaj +1 more source
Prospecting the protein design landscape
FEBS Letters, EarlyView.This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona +4 more
wiley +1 more source
Exploring circularity in African cities: barriers and opportunities for meaningful action
Environmental Research: Infrastructure and SustainabilityAs African cities are on the frontline of a poly-crisis (Allouche et al 2023), the need for local action becomes more apparent. Local government authorities (LGAs) are uniquely positioned as crucial actors to address resource security, climate change ...
Zakiyya Atkins +3 more
doaj +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
A Decade of improvement for local government
Commonwealth Journal of Local Governance, 2010 The theme of this year’s Commonwealth Local Government Conference was Improving local government: the Commonwealth vision. This theme is fundamental to all of us working in and with local government, but particularly so in the current economic climate ...
Susan Rhodes
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