Results 41 to 50 of about 1,484,142 (362)

Local Governments’ Cultural Policies

open access: yesİmgelem
Local governments’ cultural policies play a strategic role in the social, economic, and cultural development of cities. These policies aim to preserve cultural diversity, support the arts, sustain cultural heritage, and strengthen social participation ...
Oğuzhan Erdoğan
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

The Dilemma of Financial Autonomy in the Management of Public Finances at the Level of Local Governments [PDF]

open access: yesOvidius University Annals: Economic Sciences Series, 2023
This research analyzes a group of municipalities in Algeria from the perspective of financial autonomy in the management of public finances at the level of local administrations.
Mohamed Mouloud Belaid   +2 more
doaj  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Certain aspects of taxation at the local level

open access: yesВісник Харківського національного університету імені В. Н. Каразіна Серія: «Право», 2022
Introduction. The article considers some aspects of taxation at the local level. The legal regulation of local taxes in Ukraine is determined.   The purpose of the article is to clarify certain aspects of taxation at the local level.
Kateryna Plotnikova
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Alignment dynamics in eGovernment: behind the scenes of local governments [PDF]

open access: yes, 2012
Local governments are increasingly swamped by the endless possibilities that arise from information and communication technologies. They are challenged to incorporate ICTs in their daily processess and strive to thus become more efficient and effective ...
Boudry, Elke, Verdegem, Pieter
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

open access: yesMolecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero   +11 more
wiley   +1 more source

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