Results 111 to 120 of about 24,015,970 (365)

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

COMP Report: CPQR technical quality control guidelines for use of positron emission tomography/computed tomography in radiation treatment planning

open access: yesJournal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Positron emission tomography with x‐ray computed tomography (PET/CT) is increasingly being utilized for radiation treatment planning (RTP). Accurate delivery of RT therefore depends on quality PET/CT data. This study covers quality control (QC) procedures required for PET/CT for diagnostic imaging and incremental QC required for RTP.
Ran Klein   +7 more
wiley   +1 more source

Holographic Trace Anomaly and Local Renormalization Group

open access: yes, 2015
The Hamilton-Jacobi method in holography has produced important results both at a renormalization group (RG) fixed point and away from it. In this paper we use the Hamilton-Jacobi method to compute the holographic trace anomaly for four- and six ...
Rajagopal, Srivatsan   +2 more
core   +1 more source

CLUSTERING OF LOCAL GROUP DISTANCES: PUBLICATION BIAS OR CORRELATED MEASUREMENTS? III. THE SMALL MAGELLANIC CLOUD [PDF]

open access: yes, 2014
Aiming at providing a firm mean distance estimate to the SMC, and thus to place it within the internally consistent Local Group distance framework we recently established, we compiled the current largest database of published distance estimates to the ...
R. Grijs, G. Bono
semanticscholar   +1 more source

The power of microRNA regulation—insights into immunity and metabolism

open access: yesFEBS Letters, EarlyView.
MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto   +2 more
wiley   +1 more source

Uniqueness of radiomic features in non‐small cell lung cancer

open access: yesJournal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose The uniqueness of radiomic features, combined with their reproducibility, determines the reliability of radiomic studies. This study is to test the hypothesis that radiomic features extracted from a defined region of interest (ROI) are unique to the underlying structure (e.g., tumor). Approach Two cohorts of non‐small cell lung cancer (
Gary Ge, Jie Zhang
wiley   +1 more source

Large localizations of finite groups [PDF]

open access: yesJournal of Algebra, 2008
We construct examples of localizations in the category of groups which take the Mathieu group $M_{11}$ to groups of arbitrarily large cardinality which are ``abelian up to finitely many generators''. The paper is part of a broader study on the group theoretic properties which are or are not preserved by localizations.
Adam J. Przeździecki   +1 more
openaire   +2 more sources

Economies of Scale and Efficiency in the Wastewater Treatment Sector: A Decision Tree Approach

open access: yesApplied Sciences
In this study, we use the efficiency analysis trees (EAT) model to evaluate the efficiency of wastewater treatment plants (WWTPs), focusing on identifying the key variables that enhance their performance.
Vicent Hernández-Chover   +3 more
doaj   +1 more source

The dynamics of isolated Local Group galaxies [PDF]

open access: yes, 2014
We measured velocities of 862 individual red giant stars in seven isolated dwarf galaxies in the Local Group: NGC 6822, IC 1613, VV 124 (UGC 4879), the Pegasus dwarf irregular galaxy (DDO 216), Leo A, Cetus and Aquarius (DDO 210).
E. Kirby   +6 more
semanticscholar   +1 more source

Identification of novel small molecule inhibitors of ETS transcription factors

open access: yesFEBS Letters, EarlyView.
ETS transcription factors play an essential role in tumourigenesis and are indispensable for sprouting angiogenesis, a hallmark of cancer, which fuels tumour expansion and dissemination. Thus, targeting ETS transcription factor function could represent an effective, multifaceted strategy to block tumour growth. The evolutionarily conserved E‐Twenty‐Six
Shaima Abdalla   +9 more
wiley   +1 more source

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