Results 51 to 60 of about 1,038,389 (257)

Serbian Health Information System (HIS) improvements 2021–2024: comparison study using stages of continuous improvement (SOCI) methodology

Health Research Policy and Systems
Background The Health Information System (HIS) in public healthcare services in Serbia was introduced in 2008, with the first comprehensive evaluation of its maturity conducted in 2021.
Bosiljka Djikanovic, Milan Kovacevic, Isidora Smigic, Marija Cvejic, Emilija Nicic, Caitlin Madevu-Matson, Steve Ollis, Vasa Curcin, Alimou Barry, Stephanie Watson-Grant   +9 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Co-designing strategies to improve advance care planning among people from culturally and linguistically diverse backgrounds with cancer: iCanCarePlan study protocol

BMC Palliative Care
Background Advance care planning (ACP) describes the process of supporting individuals at any age or stage of health to consider and share their personal values, life goals, and preferences regarding future health care. Engaging in ACP is associated with
Ashfaq Chauhan, Upma Chitkara, Ramya Walsan, Ursula M. Sansom-Daly, Elizabeth Manias, Davinia Seah, Angie Dalli, Nadine El-Kabbout, Thit Tieu, Mashreka Sarwar, Misbah Faiz, Nancy Huang, Vitor Moraes Rocha, Abhijit Pal, Reema Harrison   +14 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

AIDS e as primeiras respostas voltadas para a epidemia: contribuições dosprofissionais de saúde [AIDS and early responses to the epidemic: contributions from health professionals]

Revista Enfermagem UERJ, 2015
Estudo descritivo qualitativo com perspectiva socio-histórica, que objetivou descrever o contexto em que surgiramas primeiras ações em resposta à epidemia da Síndrome da Imunodeficiência Adquirida (AIDS) em Florianópolis-SC, Brasil.O marco histórico ...
Isabel Cristina Alves Maliska, Maria Itayra Padilha, Selma Regina Andrade   +2 more
doaj  

Avaliação da Rede de Atenção à Saúde de pequenos municípios na ótica das equipes gestoras

Saúde em Debate
Estudo de caso com objetivo de analisar a Rede de Atenção à Saúde em dois municípios de pequeno porte, baseado nos elementos institucionais que configuram o padrão de interdependência em rede e na análise de atributos que indicam o nível de integração da
Cássia Regina Gotler Medeiros, Tatiana Engel Gerhardt   +1 more
doaj   +1 more source

Active Women over 50 online information and support to promote physical activity behaviour change: study protocol for a pilot trial

Pilot and Feasibility Studies, 2020
Background Physical activity has many physical and mental health benefits and can delay the development of disability in older age. However, uptake of this health behaviour is sub-optimal in women in their middle and older age.
Geraldine Wallbank, Catherine Sherrington, Leanne Hassett, Dominika Kwasnicka, Josephine Y. Chau, Fiona Martin, Philayrath Phongsavan, Anne Grunseit, Colleen Canning, Marian Baird, Roberta Shepherd, Anne Tiedemann   +11 more
doaj   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source