Results 61 to 70 of about 1,038,389 (257)
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
What drives participation? A look at personal influences on Tanzanian nurses in project ECHO
Human Resources for HealthIntroduction The Project Extension for Community Health Care Outcomes (Project ECHO) is a renowned collaborative model of medical education and care management.
Godfrey Kacholi +3 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
[Public health, local health units, and the Brazilian health system].
Cadernos de saude publica, 2005 This article focuses on the development of public health in Brazil, with the aim of analyzing the present process of decentralization of health care. The authors argue that the neoliberal or conservative position is unable to offer a reasonable solution to problems in the health care system.
E E, Merhy, M S, Queiroz
openaire +1 more source
Interface: Comunicação, Saúde, Educação, 2006 The article presents a proposal of a methodology aimed to analyze the health care sector according to the dynamics of capital accumulation. That approach could be summed up to more traditional approaches founded in the Public Health field, based in a ...
Maria de Fátima Siliansky de Andreazzi +2 more
doaj +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
Cadernos de Saúde PúblicaA proposta do presente trabalho é a de expor, a partir das experiências dos autores, alguns problemas que se apresentam no atual processo de implantação dos distritos sanitários indígenas, relacionados à organização dos serviços de saúde segundo o ...
Renato Athias, Marina Machado
doaj
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Cadernos de Saúde PúblicaO trabalho discute as bases sócio-culturais do controle social em saúde indígena. A reflexão pauta-se em dois eixos principais: (1) o exercício do controle social no plano local e no funcionamento de conselhos locais ou distritais de saúde e (2) a ...
Luiza Garnelo, Sully Sampaio
doaj