Results 111 to 120 of about 2,033,218 (305)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Bronze and Iron Bracelets of the Barbashinsky Burial Ground from the Excavation by A.S. Bashkirov in 1921

Археология евразийских степей
The Barbashinsky burial ground on the territory of Samara is the largest Mordovian burial ground of the Golden Horde period in the Samara Trans-Volga region. In 1921, A.S.
Natalia I. Glazistova
doaj   +1 more source

Using a local historical figure as a stimulus for history in the English National Curriculum: Samuel Plimsoll and Bristol

, 2010
Exploring cross-curricular strategies for teaching local history in the primary ...
Screech, Ben
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Local Government History and Localism

Policy Quarterly, 2019
The received view of state development in New Zealand is that the abolition of the ‘provincial system’ in 1876 set in motion the inexorable rise of centralised authority. The counter thesis presented in this article argues that until about 1940 central  politicians, irrespective of party, were consistently engaged in empowering rather than diminishing ...
openaire   +2 more sources

Lila Coley Colleyville History Collection

, 2002
The project was inspired by the 1986 sesquicentennial of Texas’ independence from Mexico. Lila Coley was a member of the Colleyville Sesquicentennial Book Committee.
Dorothy Web Albertch
core  

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Lessons from history point to local councils’ role in Australia’s recovery [PDF]

, 2020
[Extract] Australia’s local governments breathed new life into embattled regional communities after the second world war. Today, this history reminds us of the role local councils and communities should play in plans to power the national recovery from ...
Brennan, Claire, White, Patrick
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stonewall Union History document

, 1988
History of the Stonewall Union, compiled internally. The history covers the founding of the organization, as well as significant court cases and actions it has taken part in from its founding to 1988.
Stonewall Columbus
core