Results 81 to 90 of about 2,033,218 (305)

The Role of "Theme" in the Clarification of the” Historiography Text” Concept [PDF]

تاریخ اسلام, 2016
The absence of an obvious image from the quiddity of historiography text has led to difficulty and complexity in conceptualizing and theorizing within the domain of theoretical studies of history.
Amir Aqayali, Abolhassan Fayyaz Anoosh, Mostafa Pirmoradiyan   +2 more
doaj  

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Аkshoky burial ground: a new monument in the system of Andronovo antiquities of Saryarka

Вестник археологии, антропологии и этнографии, 2017
In recent years, archaeological studies have covered a group of Fedorovo monuments, which demonstrate a «pure» line of development (Besoba, Sherubai-1, Bada, etc.). A multigrave structure 1 excavated at the Akshoky burial is one of these complexes.
Kukushkin I.A., Zhusupov D.S., Dmitriev E.A.   +2 more
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

YARATKULOVO – A NEW H-CHONDRITE IN THE URALS: MINERALOGICAL DATA [PDF]

Минералогия, 2017
The Yaratkulovo meteorite was found in 2016 in the Argayash district of the Chelyabinsk region. It is a «chondrite breccia», in which the light coarse-grained fragments (primary chondrite) occur in the dark fine-grained matrix (impact assemblages ...
V.V. Sharygin, S.V. Kolisnichenko
doaj  

[Traces of epidemics in the fringes of pain: memory of Spanish flu from a local history perspective, Botucatu (São Paulo state), 1918]. [PDF]

Hist Cienc Saude Manguinhos, 2023
Ribeiro ACRC, Marques MCDC.
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Local history departments in higher educational institutions in the late 1980-ies – 1990-ies (local aspect)

Вестник Самарского университета: История, педагогика, филология
The purpose of the article is to reveal the content and features of functioning of university departments specializing in local history in the 1980-ies–1990-ies using the example of Omsk, since these processes have not been sufficiently studied.
L. I. Keller, V. G. Ryzhenko
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source