Results 71 to 80 of about 12,044,738 (293)
Molecular Oncology, EarlyView.BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi +11 more
wiley +1 more source
Acta Botânica Brasílica, 2019 Amazonian peoples use and manage plant populations in previously domesticated landscapes, but the extent of landscape transformation remains uncertain, especially in interfluvial areas.
Maria Julia Ferreira +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Land, 2019 The present study revealed how local socioecological knowledge elucidated during participatory rural appraisals and historical remote sensing data can be combined for analyzing land use change patterns from 1954 to 2007 in northwestern Vietnam.
Thanh Thi Nguyen +4 more
doaj +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
FEBS Open Bio, EarlyView.The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.In this study, we developed a deep learning method for mitotic figure counting in H&E‐stained whole‐slide images and evaluated its prognostic impact in 13 external validation cohorts from seven different cancer types. Patients with more mitotic figures per mm2 had significantly worse patient outcome in all the studied cancer types except colorectal ...
Joakim Kalsnes +32 more
wiley +1 more source
Remote Sensing, 2016 The idea that closer things are more related than distant things, known as ‘Tobler’s first law of geography’, is fundamental to understanding many spatial processes.
Carl Salk +3 more
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
The Lived Space: Possession, Ownership, and Land Sales on the Chilean Frontier (Valdivia, 1790-1830)
Historia Crítica, 2018 By looking into sales of indigenous land in the territory of Valdivia between 1790 and 1830, this article discusses how legal interactions were tied to the local spaces of rural habitation.
Manuel Bastias Saavedra
doaj +1 more source
Clusters and knowledge: local buzz, global pipelines and the process of knowledge creation
, 2004 The paper is concerned with spatial clustering of economic activity and its relation to the spatiality of knowledge creation in interactive learning processes.
H. Bathelt, A. Malmberg, P. Maskell
semanticscholar +1 more source