Results 51 to 60 of about 571,170 (255)

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Calibration of local earthquake magnitudes in Nepal

Journal of Nepal Geological Society, 2011
An attempt has been made to calibrate magnitudes of local earthquakes recorded by National Seismological Centre (NSC) of the Department of Mines and Geology (DMG), Nepal with other magnitudes of corresponding earthquakes [eported by International Seismological Centre (ISC), UK, and United States Geological Survey (USGS), USA.
S. Rajaure, B. P. Koirala, M. Bhattarai, S. Maske   +3 more
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Small‐Magnitude Seismic Swarms in Central Utah (US): Interactions of Regional Tectonics, Local Structures and Hydrothermal Systems

Geochemistry, Geophysics, Geosystems, 2023
Swarms in Central Utah are situated in the complex transition between the Basin and Range (BR) province and the Colorado Plateau. Transecting transverse structures, volcanic deposits, and hydrothermal systems complicate the extensional BR horst and ...
G. M. Petersen, K. L. Pankow
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Local spin valve effect in lateral (Ga,Mn)As/GaAs spin Esaki diode devices

AIP Advances, 2011
We report here on a local spin valve effect observed unambiguously in lateral all-semiconductor all-electrical spin injection devices, employing p+ −(Ga,Mn)As/n+ −GaAs Esaki diode structures as spin aligning contacts.
M. Ciorga, C. Wolf, A. Einwanger, M. Utz, D. Schuh, D. Weiss   +5 more
doaj   +1 more source

Empirical relationships of earthquake magnitude scales and estimation of Guttenberg–Richter parameters in gulf of Guinea region

Scientific African, 2019
Attempts have been made to investigate the relationships between various earthquake magnitude scales for the region of the Gulf of Guinea, namely moment magnitude (Mw), surface wave magnitude (Ms), body wave magnitude (mb) and local magnitude (ML).
Ayodeji Adekunle Eluyemi, Santanu Baruah, Saurabh Baruah   +2 more
doaj   +1 more source

Using the Local Phase of the Magnitude of the Local Structure Tensor for Image Registration [PDF]

, 2011
The need of image registration is increasing, especially in the medical image domain. The simplest kind of image registration is to match two images that have similar intensity. More advanced cases include the problem of registering images of different intensity, for which phase based algorithms have proven to be superior. In some cases the phase based
Anders Eklund 0002, Daniel Forsberg, Mats T. Andersson, Hans Knutsson   +3 more
openaire   +2 more sources

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source