Results 101 to 110 of about 13,032,400 (279)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Local mechanical properties of irradiated cross-linked HDPE

Materiali in tehnologije, 2018
TBU in Zlin [IGA/FT/2017/010]; Ministry of Education, Youth and Sports of the Czech Republic within the National Sustainability Programme [LO1303 (MSMT-7778/2014)]; European Regional Development Fund under project CEBIA-Tech [CZ.1.05/2.1.00/03.0089]
Hýlová, Lenka, Maňas, David, Maňas, Miroslav, Gajzlerová, Lenka, Mizera, Aleš   +4 more
openaire   +2 more sources

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Methods for Characterization and Continuum Modeling of Inhomogeneous Properties of Paper and Paperboard Materials: A Review

BioResources
The potential of paper and paperboard as fiber-based materials capable of replacing conventional polymer-based materials has been widely investigated and evaluated.
Cedric Wilfried Sanjon, Yuchen Leng, Marek Hauptmann, Peter Groche, Jens-Peter Majschak   +4 more
doaj   +2 more sources

Proceedings of the 14th International Conference on Local Mechanical Properties - LMP 2019

Acta Polytechnica CTU Proceedings, 2020
The 14th International Conference on Local Mechanical Properties was organized by the Czech Technical University in Prague, Faculty of Civil Engineering.
Editorial, Foreword
doaj  

Investigation into the Mechanical Properties and Microstructure of a Local and an Imported Reinforcement Bar

ABUAD Journal of Engineering Research and Development (AJERD)
This study investigates the mechanical properties and microstructure of locally manufactured and imported steel reinforcement bars, which are used in industrial and wastewater settings. Imported Steel (Brazilian steel) and local steel (Land craft industrial Steel) were used for the experiment.
Maureen Olere Oisakede, Kasturie Premlall, Abimbola Patricia Popoola   +2 more
openaire   +2 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Effect of the over-ageing treatment on the mechanical properties of AA2024 aluminum alloy. [PDF]

, 2012
The evolution of the hardness of the over-ageing AA2024 alloy scale was followed by measurements of Vickers hardness. The nanoindentation is adapted to the determination of elastoplastic properties (hardness and Young’s modulus) of the matrix and also of
Alexis, Joël, Vulpe, Sanda, Radutoiu, Nicoleta, Abrudeanu, Marioara, Marioara Abrudeanu, Petit, Jacques-Alain, Lacroix, Loïc, Rizea, Vasile, Vasile Rizea, Nicoleta Radutoiu, Jacques-Alain Petit, Joël Alexis, Loic Lacroix, Sanda Vulpe   +13 more
core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source