Results 81 to 90 of about 289,474 (258)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Microstructure and Thermal Mechanical Behavior of Arc-Welded Aluminum Alloy 6061-T6

Journal of Manufacturing and Materials Processing
In this study, the welding thermal cycle, as well as the microstructural and mechanical properties of welded AA6061-T6 plates, were studied. The plates were prepared and bead-on-plate welded using gas metal arc welding (GMAW). Numerical simulations using
Zeli Arhumah, Xuan-Tan Pham
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Local mechanical properties of nanostructured polymer surfaces

, 2022
2021 Spring Meeting of the European Materials Research Society (E-MRS) to be held as a VIRTUAL Conference from May 31st to June 3rd, 2021. (The VIRTUAL 2021 Spring Meeting will consist of parallel symposia with invited speakers, oral and poster presentations, assorted by plenary sessions and a number of workshops and training courses.) .-https://www ...
Martínez-Tong, Daniel E., Rodríguez-Beltrán, René, I., Ezquerra, Tiberio A., Moreno, Pablo, Rebollar, Esther   +4 more
openaire   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Methods for Characterization and Continuum Modeling of Inhomogeneous Properties of Paper and Paperboard Materials: A Review

BioResources
The potential of paper and paperboard as fiber-based materials capable of replacing conventional polymer-based materials has been widely investigated and evaluated.
Cedric Wilfried Sanjon, Yuchen Leng, Marek Hauptmann, Peter Groche, Jens-Peter Majschak   +4 more
doaj   +2 more sources

Proceedings of the 14th International Conference on Local Mechanical Properties - LMP 2019

Acta Polytechnica CTU Proceedings, 2020
The 14th International Conference on Local Mechanical Properties was organized by the Czech Technical University in Prague, Faculty of Civil Engineering.
Editorial, Foreword
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source