Results 71 to 80 of about 289,474 (258)

A Fatigue Life Calculation Procedure Implementing Surface and Depth-Graded Mechanical Properties

Engineering Proceedings
This study presents a fatigue life prediction procedure for high-strength steel suspension components that exhibit surface and depth-graded mechanical properties due to manufacturing processes such as shot peening and heat treatment.
Paschalis Adamidis, Christos Gakias, Efstratios Giannakis, Georgios Savaidis   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Multiscale analysis of mechanical behavior of multilayer steel structures fabricated by wire and arc additive manufacturing

Science and Technology of Advanced Materials, 2020
The mechanical behavior of multilayer steel structures fabricated via wire and arc additive manufacturing (WAAM) has been investigated from the multiscale perspective.
Ikumu Watanabe, Zhengzhong Sun, Houichi Kitano, Kenta Goto   +3 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Mechanical properties and local damage evolution of granulite under water-rock interactions

Yantu gongcheng xuebao
Water-rock interaction is a crucial inducing factor for the damage and instability of surrounding rocks in deep underground engineering. Using uniaxial compression tests, digital image correlation technology, and microstructure tests, this study ...
WANG Lunan 1, 2, PANG Yibo 1, YIN Xiaomeng 3, ZHANG Jiahao 1, BAI Hongyu 1
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Microstructural Analysis of Austempered Ductile Iron Castings

Hittite Journal of Science and Engineering, 2016
A ustempered ductile iron ADI castings have a wide range of application areas in engineering designs due to their promising mechanical properties and lower cost.
Baris Cetin, Kemal Davut, Ebru Arslan, Mustafa Can Uzun, Halim Meco   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Quantifying the impact of oxidation on the mechanical properties of Alloy 718 using local mechanical testing techniques

Materials & Design
Despite excellent oxidative properties of the Alloy 718 Ni-based superalloy, long-term exposure to oxidative environments in service creates a chemical gradient in the sub-surface affected by oxidation.
Malo Jullien, Marc Legros, Mathieu Calvat, Jean-Charles Stinville, Damien Texier   +4 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source