Results 81 to 90 of about 4,363,339 (298)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Emerging Forms of Hyperlocal Media
Nordicom Review, 2019 In the Nordic countries, local and regional newspapers have functioned as keystone media. This article examines the emergence of hyperlocal initiatives as part of evolving local media ecosystems in Finland, analysing the extent and characteristics of ...
Hujanen Jaana +3 more
doaj +1 more source
Birefringence in nonlinear anisotropic dielectric media
, 2006 Light propagation is investigated in the context of local anisotropic nonlinear dielectric media at rest with the dielectric coefficients $\epsilon^\mu{}_\nu = \epsilon^\mu{}_\nu (\vec{E},\vec{B})$ and constant $\mu$, in the limit of geometrical optics ...
D. H. Teodoro +11 more
core +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
International Journal of CommunicationDigital news media have struggled to find the most sustainable business model to survive and thrive in recent years. Current research has paid little attention to this problem at the local level in non-Western and peripheral media systems.
Antoine Faure +3 more
doaj +2 more sources
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Retracted: Local Media Image Propagation Algorithm and Its Governance in the Age of Artificial Intelligence. [PDF]
Appl Bionics Biomech, 2023 And Biomechanics AB.
europepmc +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Energy Transition in and by the Local Media
Nordicom Review, 2013 Climate change mitigation and the transition to environmentally sustainable forms of life have become central public issues, and a number of studies have investigated the role of the media in constructing and distributing representations of climate ...
Horsbøl Anders
doaj +1 more source