Results 151 to 160 of about 225,629 (280)

Single‐Cell Metabolic Imaging and Digital Scoring of Fat Tissue Remodeling by Label‐Free Metabolic Microscopy

Advanced Science, EarlyView.
Mid‐infrared optoacoustic microscopy (MiROM) acquires lipid‐ and protein‐ associated vibrational contrast in intact fat tissue without dyes, preserving native tissue architecture. Through lateral and axial segmentation, MiROM tracks intrinsic intracellular changes during postnatal remodeling. A quantitative spatial analysis tool (Q‐SAT) maps white‐ and
Myeongseop Kim, Constantin Berger, Alexander Wolf, Alina Peteranderl, Martin Klingenspor, Vasilis Ntziachristos, Yongguo Li, Miguel A. Pleitez   +7 more
wiley   +1 more source

The Signal in the Extreme: A Systematic Outlier Framework Identifies Discrete Immunometabolic Subtypes in Human and Cellular Models. [PDF]

Med Sci (Basel)
Garcia-Coste JJ, Aguayo-Cerón KA, Espinosa-Raya J, García-Rivero AA, López-Leyva C, Gutiérrez-Rojas RA, Vargas-De-León C, Romero-Nava R.   +7 more
europepmc   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

A new hybrid model for improving outlier detection using combined autoencoder and variational autoencoder. [PDF]

Sci Rep
Daoud AM, Elkomy OM, Khedr WI, Hosny KM.
europepmc   +1 more source

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

Detecting outliers in rule-based knowledge bases using Self-Organizing Map and Local Outlier Factor algorithms

Procedia Computer Science, 2023
Czesław Horyń, Agnieszka Nowak Brzezińska   +1 more
openaire   +1 more source

3D Bioprinted Fat‐Myocardium Model Unravels the Role of Adipocyte Hypertrophy in Atrial Dysfunction

Advanced Science, EarlyView.
A human‐derived 3D bioprinted fat–myocardium model is developed to investigate how adipocyte hypertrophy drives atrial dysfunction in obesity. Palmitate‐induced adipocyte hypertrophy promotes adipose dysfunction that impairs atrial cardiomyocyte metabolism and electrophysiology through both paracrine and direct interactions. This platform recapitulates
Lara Ece Celebi, Pinar Zorlutuna
wiley   +1 more source

International testing and refinement of AI algorithms predicting acute leukemia subtypes from routine laboratory data. [PDF]

Nat Commun
Turki AT, Fan Y, Hernández-Sánchez A, Silva W, Fleming S, Yalcin K, Van Elssen CHMJ, Madanat Y, Karasek M, Aljurf M, Della Porta MG, Martinez-Roca A, Guarnera L, Steffen K, Antoniou E, Rivas MM, Mishra DK, Blum AT, Manantsoa SN, Adiat A, Enshaei A, Thol F, Voso MT, Chen J, Elhassan TA, Moorman AV, Vidriales MB, Neuendorff NR, Koc A, Mishra P, Strumberg D, Fourmanov RS, Heine L, Kleesiek J, Munárriz D, Asti G, Mokoonlall M, Kometas M, Rego E, Mecklenbrauck R, Sobas M, Wu D, Nensa F, Engelke M.   +43 more
europepmc   +1 more source

Engineering Compact Base Editors by AlphaFold‐Guided Mutation Scan and Escherichia coli‐Based Tri‐Selection

Advanced Science, EarlyView.
A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son, Goeun Kim, Jungjoon K. Lee   +2 more
wiley   +1 more source

Climate Extremes, Genomic Coverage, and Taxonomy Shape the Detection of Adaptation: A Systematic Review of GEA Studies for the Kingdom Animalia. [PDF]

Mol Ecol
Williams AK, Ruppert OM, Landguth EL.
europepmc   +1 more source