Results 61 to 70 of about 1,764 (213)

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Reconstructing the Narrative of Rape in the Kibbutz by the Israeli Press

open access: yesInternational Journal of Conflict and Violence, 2009
The author proposes that national press coverage of sex crimes in Israeli kibbutzim is intended to restructure the public’s perception by showing that such crimes are a symptom of broader social problems. Articles about a rape incident in Kibbutz Shomrat
Efrat Shoham
doaj   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

open access: yesMolecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu   +13 more
wiley   +1 more source

Débats médiatisés et numériques sur la sécheresse. Le cas des pénuries d’eau dans un climat semi-aride en Arizona

open access: yesCommuniquer
This article aims to analyze the publicization of debates on public policy orientations, sociotechnical choices, and alternative solutions proposed by stakeholders to address situations of drought and water scarcity.
Anne-Lise Boyer   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Latin America’s Transformative New Extraction and Local Conflicts

open access: yesEuropean Review of Latin American and Caribbean Studies, 2015
Subterranean Struggles: New Dynamics of Mining, Oil, and Gas in Latin America, edited by Anthony Bebbington and Jeffrey Bury. University of Texas Press, 2013.Unearthing conflict: Corporate Mining, Activism, and Expertise in Peru, by Fabiana Li.
Barbara Hogenboom
doaj   +1 more source

Presse locale, un média de diversion [PDF]

open access: yesRéseaux, 2008
L’information locale en France est, en apparence, diverse et neutre. Une analyse de contenu de la presse régionale bretonne montre au contraire qu’elle demeure marquée par une vision du monde très hiérarchisée et privilégiant la stabilité sociale. D’une société faite d’interrelations et de processus dynamiques, elle ne retient qu’une juxtaposition de ...
openaire   +3 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Las fuentes del conocimiento histórico contemporáneo. Potencialidades de los textos periodísticos/The sources of contemporary historical knowledge. Potentialities of journalistic texts

open access: yesPedagogía y Sociedad
Introducción: El artículo analiza las fuentes del conocimiento en el proceso de enseñanza-aprendizaje de la Historia y las potencialidades de los textos periodísticos.
Jhoannis Jacinto Rodríguez Avalos   +5 more
doaj  

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