Results 51 to 60 of about 7,662,913 (346)
An optimal solution for software testing case generation based on particle swarm optimization
Open Physics, 2018 Searching based testing case generation technology converts the problem of testing case generation to function optimizations, through a fitness function, which is usually optimized using heuristic search algorithms.
Jianqi Shi +3 more
doaj +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
ISPRS International Journal of Geo-Information, 2015 Vehicle routing optimization (VRO) designs the best routes to reduce travel cost, energy consumption, and carbon emission. Due to non-deterministic polynomial-time hard (NP-hard) complexity, many VROs involved in real-world applications require too much ...
Wei Tu +3 more
doaj +1 more source
Hardness of Continuous Local Search: Query Complexity and Cryptographic Lower Bounds
ACM-SIAM Symposium on Discrete Algorithms, 2017 Local search proved to be an extremely useful tool when facing hard optimization problems (e.g., via the simplex algorithm, simulated annealing, or genetic algorithms).
Pavel Hubácek, E. Yogev
semanticscholar +1 more source
Local Search for Max-Sum Diversification [PDF]
ACM-SIAM Symposium on Discrete Algorithms, 2016 We provide simple and fast polynomial time approximation schemes (PTASs) for several variants of the max-sum diversification problem which, in its most basic form, is as follows: Given n points p_1,...,p_n in R^d and an integer k, select k points such ...
Alfonso Cevallos +2 more
semanticscholar +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Applied Sciences, 2021 Several interesting libraries for optimization have been proposed. Some focus on individual optimization algorithms, or limited sets of them, and others focus on limited sets of problems.
Illya Bakurov +4 more
doaj +1 more source
Self-Adaptive Gravitational Search Algorithm With a Modified Chaotic Local Search
IEEE Access, 2017 The gravitational search algorithm (GSA) has been proved to yield good performance in solving various optimization problems. However, it is inevitable to suffer from slow exploitation when solving complex problems.
Junkai Ji +5 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source