Results 61 to 70 of about 794,304 (306)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Enhanced algorithms for Local Search [PDF]
Information Processing Letters, 2006 Let G=(V,E) be a finite graph, and f:V->N be any function. The Local Search problem consists in finding a local minimum of the function f on G, that is a vertex v such that f(v) is not larger than the value of f on the neighbors of v in G. In this note, we first prove a separation theorem slightly stronger than the one of Gilbert, Hutchinson and ...
openaire +3 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Stochastic local search for SMT: combining theory solvers with WalkSAT [PDF]
, 2011 This is the author’s accepted manuscript. The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-642-24364-6_12.acmid: 2050798 location: Saarbrücken, Germany numpages: 16acmid: 2050798 location: Saarbrücken, Germany ...
Roberto Sebastiani +9 more
core +1 more source
Evolutionary Multi-objective Optimization for Multi-depot Vehicle Routing in Logistics
International Journal of Computational Intelligence Systems, 2017 Delivering goods in an efficient and cost-effective way is always a challenging problem in logistics. In this paper, the multi-depot vehicle routing is focused. To cope with the conflicting requirements, an advanced multi-objective evolutionary algorithm
Xiaowen Bi, Zeyu Han, Wallace K. S. Tang
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Production, 2006 Neste trabalho, foi desenvolvida uma nova heurística de localização-alocação (HLA) para problemas de localização de facilidades (facility). Em tais problemas a questão central é localizar um objeto ou mais objetos, que são chamados de facilidades, e ...
Reinaldo Gen Ichiro Arakaki +1 more
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Experiments to shed light on the best way to use Iterated Local Search for a complex combinatorial problem [PDF]
, 2007 Iterated Local Search (ILS) is a popular metaheuristic search technique for use on combinatorial optimisation problems. As with most such techniques, there are many ways in which ILS can be implemented.
Wright, M B
core
Journal of Intelligent Systems, 2019 In this research, different optimization models are developed to solve the preventive maintenance (PM) optimization problem in a maintainable multi-state series–parallel system.
Maatouk Imane +3 more
doaj +1 more source