Results 61 to 70 of about 9,166,026 (293)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Evolutionary Multi-objective Optimization for Multi-depot Vehicle Routing in Logistics
International Journal of Computational Intelligence Systems, 2017 Delivering goods in an efficient and cost-effective way is always a challenging problem in logistics. In this paper, the multi-depot vehicle routing is focused. To cope with the conflicting requirements, an advanced multi-objective evolutionary algorithm
Xiaowen Bi, Zeyu Han, Wallace K. S. Tang
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Local search for the maximumk-plex problem
, 2020 The maximum k-plex problem is an important, computationally complex graph based problem. In this study an effective k-plex local search (KLS) is presented for solving this problem on a wide range of graph types.
Pullan, Wayne
core +1 more source
Production, 2006 Neste trabalho, foi desenvolvida uma nova heurística de localização-alocação (HLA) para problemas de localização de facilidades (facility). Em tais problemas a questão central é localizar um objeto ou mais objetos, que são chamados de facilidades, e ...
Reinaldo Gen Ichiro Arakaki +1 more
doaj +1 more source
FEBS Letters, EarlyView.Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav +2 more
wiley +1 more source
Journal of Intelligent Systems, 2019 In this research, different optimization models are developed to solve the preventive maintenance (PM) optimization problem in a maintainable multi-state series–parallel system.
Maatouk Imane +3 more
doaj +1 more source
An Improved SPEA2 Algorithm with Local Search for Multi-Objective Investment Decision-Making
Applied Sciences, 2019 Enterprise investment decision-making should not only consider investment profits, but also investment risks, which is a complex nonlinear multi-objective optimization problem.
Xi Liu, Dan Zhang
doaj +1 more source
Scheduling Algorithms for a Hybrid Flow Shop under Uncertainty
Algorithms, 2020 In modern production systems, scheduling problems have to be solved in consideration of frequently changing demands and varying production parameters.
Christin Schumacher, Peter Buchholz
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source