Results 81 to 90 of about 3,752,335 (283)
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
Finding the Best 3-OPT Move in Subcubic Time
Algorithms, 2020 Given a Traveling Salesman Problem solution, the best 3-OPT move requires us to remove three edges and replace them with three new ones so as to shorten the tour as much as possible.
Giuseppe Lancia, Marcello Dalpasso
doaj +1 more source
Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum
FEBS Open Bio, EarlyView.Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik +6 more
wiley +1 more source
GraphRAG on Technical Documents - Impact of Knowledge Graph Schema [PDF]
Transactions on Graph Data and KnowledgeRetrieval Augmented Generation (RAG) is seeing rapid adoption in industry to enable employees to query information captured in proprietary data for their organisation.
Scaffidi, Henri +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Policy Search: Any Local Optimum Enjoys a Global Performance Guarantee [PDF]
, 2013 Local Policy Search is a popular reinforcement learning approach for handling large state spaces. Formally, it searches locally in a paramet erized policy space in order to maximize the associated value function averaged over some predefined distribution.
Geist, Matthieu, Scherrer, Bruno
core +3 more sources
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source
Connection Science, 2019 This paper presents a procedure which composes music pieces through handling four layers in music, namely pitches, rhythms, dynamics, and timber. As an innovative feature, the procedure uses the combination of a genetic algorithm with a synergetic ...
Reza Zamani
doaj +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
An Efficient Local Search Algorithm for the Minimum
IEEE Access, 2018 The minimum $k$ -dominating set (MKDS) problem, a generalization of the classical minimum dominating set problem, is an important NP-hard combinatorial optimization problem with various applications.
Ruizhi Li +4 more
doaj +1 more source