Results 91 to 100 of about 9,166,026 (293)
Connection Science, 2019 This paper presents a procedure which composes music pieces through handling four layers in music, namely pitches, rhythms, dynamics, and timber. As an innovative feature, the procedure uses the combination of a genetic algorithm with a synergetic ...
Reza Zamani
doaj +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
A discrete Jaya algorithm for vehicle routing problems with uncertain demands
Systems Science & Control EngineeringVehicle Routing Problem with Uncertain Demands (VRPUD) is one of the research hotspots in the field of logistics scheduling. In this paper, a Discrete Jaya (DJaya) algorithm is presented for the VRPUD to minimize the total cost.
Jing Zhang +3 more
doaj +1 more source
An Efficient Local Search Algorithm for the Minimum
IEEE Access, 2018 The minimum $k$ -dominating set (MKDS) problem, a generalization of the classical minimum dominating set problem, is an important NP-hard combinatorial optimization problem with various applications.
Ruizhi Li +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Variable neighbourhood decomposition search for 0-1 mixed integer programs [PDF]
, 2009 In this paper we propose a new hybrid heuristic for solving 0-1 mixed integer programs based on the principle of variable neighbourhood decomposition search. It combines variable neighbourhood search with a general-purpose CPLEX MIP solver.
Hanafi, S +7 more
core +1 more source
Parallel BVH Construction Using Locally Density Clustering
IEEE Access, 2019 A novel bounding volume hierarchy (BVH) construction method based on locally dense clustering (LDC) was proposed for the low quality of BVH constructed in a complex scene with uneven distribution of primitives.
Yingsong Hu +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
A Monarch Butterfly Optimization for the Dynamic Vehicle Routing Problem
Algorithms, 2017 The dynamic vehicle routing problem (DVRP) is a variant of the Vehicle Routing Problem (VRP) in which customers appear dynamically. The objective is to determine a set of routes that minimizes the total travel distance.
Shifeng Chen, Rong Chen, Jian Gao
doaj +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source