Results 71 to 80 of about 3,752,335 (283)

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

Distributed localized bi-objective search [PDF]

open access: yesEuropean Journal of Operational Research, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Derbel, Bilel   +3 more
openaire   +4 more sources

Local Search in Unstructured Networks

open access: yes, 2002
We review a number of message-passing algorithms that can be used to search through power-law networks. Most of these algorithms are meant to be improvements for peer-to-peer file sharing systems, and some may also shed some light on how unstructured ...
Adamic, Lada A.   +2 more
core   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

open access: yesFEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold   +11 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Local search for stable marriage problems

open access: yes, 2010
The stable marriage (SM) problem has a wide variety of practical applications, ranging from matching resident doctors to hospitals, to matching students to schools, or more generally to any two-sided market.
Gelain, M.   +4 more
core   +3 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

open access: yesFEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman   +4 more
wiley   +1 more source

Complete local search with memory [PDF]

open access: yes
Neighborhood search heuristics like local search and its variants are some of the most popular approaches to solve discrete optimization problems of moderate to large size. Apart from tabu search, most of these heuristics are memoryless. In this paper we
Ghosh, D., Sierksma, G.
core   +1 more source

Efficient Hill Climber for Multi-Objective Pseudo-Boolean Optimization [PDF]

open access: yes, 2016
Chicano, F., Whitley D., & Tinós R. (2016). Efficient Hill Climber for Multi-Objective Pseudo-Boolean Optimization. 16th European Conference on Evolutionary Computation for Combinatorial Optimization (LNCS 9595), pp.
Chicano, Francisco   +2 more
core  

Combinatorial Optimization by Iterative Partial Transcription

open access: yes, 1999
A procedure is presented which considerably improves the performance of local search based heuristic algorithms for combinatorial optimization problems.
A. Möbius   +4 more
core   +2 more sources

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