Results 71 to 80 of about 794,304 (306)

An Improved SPEA2 Algorithm with Local Search for Multi-Objective Investment Decision-Making

Applied Sciences, 2019
Enterprise investment decision-making should not only consider investment profits, but also investment risks, which is a complex nonlinear multi-objective optimization problem.
Xi Liu, Dan Zhang
doaj   +1 more source

Scheduling Algorithms for a Hybrid Flow Shop under Uncertainty

Algorithms, 2020
In modern production systems, scheduling problems have to be solved in consideration of frequently changing demands and varying production parameters.
Christin Schumacher, Peter Buchholz
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Monotone Submodular Maximization over a Matroid via Non-Oblivious Local Search [PDF]

, 2013
We present an optimal, combinatorial 1−1/e approximation algorithm for monotone submodular optimization over a matroid constraint. Compared to the continuous greedy algorithm (Calinescu, Chekuri, Pál and Vondrák, 2008), our algorithm is extremely simple ...
Filmus, Yuval, Yuval Filmus, Justin Ward, Ward, Justin   +3 more
core   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Variable neighbourhood decomposition search for 0-1 mixed integer programs

, 2009
In this paper we propose a new hybrid heuristic for solving 0-1 mixed integer programs based on the principle of variable neighbourhood decomposition search. It combines variable neighbourhood search with a general-purpose CPLEX MIP solver.
Hanafi, S, Nenad Mladenović, Jasmina Lazić, Mladenović, N, Urosevic, D, Dragan Urošević, Lazic, J, Saïd Hanafi   +7 more
core   +1 more source

Search-based fault localization [PDF]

2011 26th IEEE/ACM International Conference on Automated Software Engineering (ASE 2011), 2011
Many spectrum-based fault localization measures have been proposed in the literature. However, no single fault localization measure completely outperforms others: a measure which is more accurate in localizing some bugs in some programs is less accurate in localizing other bugs in other programs.
Shaowei Wang 0002, David Lo 0001, Lingxiao Jiang, Lucia, Hoong Chuin Lau   +4 more
openaire   +2 more sources

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Progress control in iterated local search for nurse rostering [PDF]

, 2011
This paper describes an approach in which a local search technique is alternated with a process which ‘jumps' to another point in the search space. After each ‘jump' a (time-intensive) local search is used to obtain a new local optimum.
Burke, Edmund, Curtois, T., T Curtois, G Post, van Ommeren, J.-K., Fijn van Draat, L., L F van Draat, Burke, E.K., E K Burke, van Draat, Laurens F, J-K van Ommeren, van Ommeren, Jan-Kees, Curtois, Tim, Post, Gerhard, Post, G.   +14 more
core   +1 more source