Results 51 to 60 of about 3,752,335 (283)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Extending Yioop! With Geographical Location Local Search [PDF]
, 2012 It is often useful when doing an internet search to get results based on our current location. For example, we might want such results when we search on restaurants, car service center, or hospitals. Current open source search engines like those based on
Sinha, Vijaya
core +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Logistic optimization of the blood delivery routing problem in the Lower Southern region of Thailand
Engineering and Applied Science Research, 2023 This study discusses a blood delivery routing problem faced by a regional blood centre (RBC). The RBC meets the requests of 21 hospitals for blood and blood products.
Kunanon Intapan +4 more
doaj
Applied Sciences, 2021 Several interesting libraries for optimization have been proposed. Some focus on individual optimization algorithms, or limited sets of them, and others focus on limited sets of problems.
Illya Bakurov +4 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Discrete Optimization, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
LANCIA, Giuseppe +2 more
openaire +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Evolutionary Multi-objective Optimization for Multi-depot Vehicle Routing in Logistics
International Journal of Computational Intelligence Systems, 2017 Delivering goods in an efficient and cost-effective way is always a challenging problem in logistics. In this paper, the multi-depot vehicle routing is focused. To cope with the conflicting requirements, an advanced multi-objective evolutionary algorithm
Xiaowen Bi, Zeyu Han, Wallace K. S. Tang
doaj +1 more source