Results 51 to 60 of about 794,304 (306)
ISPRS International Journal of Geo-Information, 2015 Vehicle routing optimization (VRO) designs the best routes to reduce travel cost, energy consumption, and carbon emission. Due to non-deterministic polynomial-time hard (NP-hard) complexity, many VROs involved in real-world applications require too much ...
Wei Tu +3 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Constraint-based local search for container freight rail scheduling [PDF]
, 2005 A traditional container rail service is based on regular timetables. This causes a risk that some customers may turn away if their preferred itinerary is not attainable and the take-up of some services in a fixed schedule may be low and therefore not ...
Indra-Payoong, Nakorn
core
A variable neighborhood search with an effective local search for uncapacitated multilevel lot-sizing problems [PDF]
, 2014 In this study, we improved the variable neighborhood search (VNS) algorithm for solving uncapacitated multilevel lot-sizing (MLLS) problems. The improvement is two-fold.
Xu, Yuchun +4 more
core +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Logistic optimization of the blood delivery routing problem in the Lower Southern region of Thailand
Engineering and Applied Science Research, 2023 This study discusses a blood delivery routing problem faced by a regional blood centre (RBC). The RBC meets the requests of 21 hospitals for blood and blood products.
Kunanon Intapan +4 more
doaj
Efficiency of Local Search with Multiple Local Optima [PDF]
SIAM Journal on Discrete Mathematics, 2001 Summary: The first contribution of this paper is a theoretical investigation of combinatorial optimization problems. Their landscapes are specified by the set of neighborhoods of all points of the search space. The aim of the paper consists of the estimation of the number N of local optima and the distributions of the sizes \((\alpha_j)\) of their ...
Josselin Garnier, Leila Kallel
openaire +2 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Applied Sciences, 2021 Several interesting libraries for optimization have been proposed. Some focus on individual optimization algorithms, or limited sets of them, and others focus on limited sets of problems.
Illya Bakurov +4 more
doaj +1 more source