Results 51 to 60 of about 9,166,026 (293)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko +5 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Febrile neutropenia (FN) is a frequent and serious complication in children receiving cancer therapy. Standardizing FN management across Asia is challenging due to variable healthcare infrastructure, diagnostic capacity, and infection patterns; however, it could improve resource use and patient outcomes.
Joliza Patricia Cañeba +29 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Logistic optimization of the blood delivery routing problem in the Lower Southern region of Thailand
Engineering and Applied Science Research, 2023 This study discusses a blood delivery routing problem faced by a regional blood centre (RBC). The RBC meets the requests of 21 hospitals for blood and blood products.
Kunanon Intapan +4 more
doaj
Enhanced algorithms for Local Search [PDF]
Information Processing Letters, 2006 Let G=(V,E) be a finite graph, and f:V->N be any function. The Local Search problem consists in finding a local minimum of the function f on G, that is a vertex v such that f(v) is not larger than the value of f on the neighbors of v in G. In this note, we first prove a separation theorem slightly stronger than the one of Gilbert, Hutchinson and ...
openaire +4 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Applied Sciences, 2021 Several interesting libraries for optimization have been proposed. Some focus on individual optimization algorithms, or limited sets of them, and others focus on limited sets of problems.
Illya Bakurov +4 more
doaj +1 more source
Complete Local Search with Memory
Journal of Heuristics, 2002 Neighborhood search heuristics like local search and its variants are some of the most popular approaches to solve discrete optimization problems of moderate to large size. Apart from tabu search, most of these heuristics are memoryless. In this paper we introduce a new neighborhood search heuristic that makes effective use of memory structures in a ...
Diptesh Ghosh, Gerard Sierksma
openaire +5 more sources
Efficiency of Local Search with Multiple Local Optima [PDF]
SIAM Journal on Discrete Mathematics, 2001 Summary: The first contribution of this paper is a theoretical investigation of combinatorial optimization problems. Their landscapes are specified by the set of neighborhoods of all points of the search space. The aim of the paper consists of the estimation of the number N of local optima and the distributions of the sizes \((\alpha_j)\) of their ...
Josselin Garnier, Leila Kallel
openaire +3 more sources
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source